Sylvie Claeysen Inserm, U1191 Institute of Functional Genomics Biography Publications Institution JoVE Articles Sylvie Claeysen has not added a biography. If you are Sylvie Claeysen and would like to personalize this page please email our Author Liaison for assistance. Publications Cerebrovascular Pathology During the Progression of Experimental Alzheimer's Disease Neurobiology of Disease. Apr, 2016 | Pubmed ID: 26774030 Serotonin: A New Hope in Alzheimer's Disease? ACS Chemical Neuroscience. Jul, 2015 | Pubmed ID: 26011650 Novel Multitarget-directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents Against Alzheimer's Disease: the Design of Donecopride Journal of Medicinal Chemistry. Apr, 2015 | Pubmed ID: 25793650 Design of Donecopride, a Dual Serotonin Subtype 4 Receptor Agonist/acetylcholinesterase Inhibitor with Potential Interest for Alzheimer's Disease Treatment Proceedings of the National Academy of Sciences of the United States of America. Aug, 2014 | Pubmed ID: 25157130 Early Administration of RS 67333, a Specific 5-HT4 Receptor Agonist, Prevents Amyloidogenesis and Behavioral Deficits in the 5XFAD Mouse Model of Alzheimer's Disease Frontiers in Aging Neuroscience. 2013 | Pubmed ID: 24399967 Serotonin Type 4 Receptor Dimers Methods in Cell Biology. 2013 | Pubmed ID: 24143975 5-HT4 Receptors Constitutively Promote the Non-amyloidogenic Pathway of APP Cleavage and Interact with ADAM10 ACS Chemical Neuroscience. Jan, 2013 | Pubmed ID: 23336052 Pharmacological Profile of Engineered 5-HT₄ Receptors and Identification of 5-HT₄ Receptor-biased Ligands Brain Research. May, 2013 | Pubmed ID: 23148949 Alzheimer Culprits: Cellular Crossroads and Interplay Cellular Signalling. Sep, 2012 | Pubmed ID: 22627093 5-HT(4) Receptors, a Place in the Sun: Act Two Current Opinion in Pharmacology. Feb, 2011 | Pubmed ID: 21342787 G Protein Activation by Serotonin Type 4 Receptor Dimers: Evidence That Turning on Two Protomers is More Efficient The Journal of Biological Chemistry. Mar, 2011 | Pubmed ID: 21247891 Benzimidazole Derivatives As New Serotonin 5-HT6 Receptor Antagonists. Molecular Mechanisms of Receptor Inactivation Journal of Medicinal Chemistry. Feb, 2010 | Pubmed ID: 20078106 Beta-arrestin1 Phosphorylation by GRK5 Regulates G Protein-independent 5-HT4 Receptor Signalling The EMBO Journal. Sep, 2009 | Pubmed ID: 19661922 Conformational Toggle Switches Implicated in Basal Constitutive and Agonist-induced Activated States of 5-hydroxytryptamine-4 Receptors Molecular Pharmacology. Apr, 2009 | Pubmed ID: 19168624 Engineering GPCR Signaling Pathways with RASSLs Nature Methods. Aug, 2008 | Pubmed ID: 18668035 5-HT(4) Receptors: History, Molecular Pharmacology and Brain Functions Neuropharmacology. Nov, 2008 | Pubmed ID: 18603269 Modifying Ligand-induced and Constitutive Signaling of the Human 5-HT4 Receptor PloS One. 2007 | Pubmed ID: 18338032 5-hydroxytryptamine 4 Receptor Activation of the Extracellular Signal-regulated Kinase Pathway Depends on Src Activation but Not on G Protein or Beta-arrestin Signaling Molecular Biology of the Cell. Jun, 2007 | Pubmed ID: 17377064 Neuronal 5-HT Metabotropic Receptors: Fine-tuning of Their Structure, Signaling, and Roles in Synaptic Modulation Cell and Tissue Research. Nov, 2006 | Pubmed ID: 16896947 Uncoupling and Endocytosis of 5-hydroxytryptamine 4 Receptors. Distinct Molecular Events with Different GRK2 Requirements The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15919661 Drosophila Molting Neurohormone Bursicon is a Heterodimer and the Natural Agonist of the Orphan Receptor DLGR2 FEBS Letters. Apr, 2005 | Pubmed ID: 15811337 An Activation Switch in the Rhodopsin Family of G Protein-coupled Receptors: the Thyrotropin Receptor The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15722344 New Sorting Nexin (SNX27) and NHERF Specifically Interact with the 5-HT4a Receptor Splice Variant: Roles in Receptor Targeting Journal of Cell Science. Oct, 2004 | Pubmed ID: 15466885 A Single Mutation in the 5-HT4 Receptor (5-HT4-R D100(3.32)A) Generates a Gs-coupled Receptor Activated Exclusively by Synthetic Ligands (RASSL) The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12441358 A Conserved Asn in TM7 of the Thyrotropin Receptor is a Common Requirement for Activation by Both Mutations and Its Natural Agonist FEBS Letters. Apr, 2002 | Pubmed ID: 12062436 A 5-HT4 Receptor Transmembrane Network Implicated in the Activity of Inverse Agonists but Not Agonists The Journal of Biological Chemistry. Jul, 2002 | Pubmed ID: 11976337 G Protein-coupled Receptors: Dominant Players in Cell-cell Communication International Review of Cytology. 2002 | Pubmed ID: 11804040 Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases Margarita Arango-Lievano1,2,3, Patrizia Giannoni1,2,3, Sylvie Claeysen1,2,3, Nicola Marchi1,2,3, Freddy Jeanneteau1,2,3 1Inserm, U1191, Institute of Functional Genomics, 2CNRS, UMR-5203, 3Université de Montpellier JoVE 54796 Medicine Primary Culture of Mouse Dopaminergic Neurons Florence Gaven1,2,3, Philippe Marin1,2,3, Sylvie Claeysen1,2,3 1CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, 2Inserm, U661, Montpellier, 3Universités de Montpellier JoVE 51751 Neuroscience
Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases Margarita Arango-Lievano1,2,3, Patrizia Giannoni1,2,3, Sylvie Claeysen1,2,3, Nicola Marchi1,2,3, Freddy Jeanneteau1,2,3 1Inserm, U1191, Institute of Functional Genomics, 2CNRS, UMR-5203, 3Université de Montpellier JoVE 54796 Medicine
Primary Culture of Mouse Dopaminergic Neurons Florence Gaven1,2,3, Philippe Marin1,2,3, Sylvie Claeysen1,2,3 1CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, 2Inserm, U661, Montpellier, 3Universités de Montpellier JoVE 51751 Neuroscience
