Wen Shan Yew Department of Biochemistry Yong Loo Lin School of Medicine Biography Publications Institution JoVE Articles Wen Shan Yew has not added a biography. If you are Wen Shan Yew and would like to personalize this page please email our Author Liaison for assistance. Publications Identification of Polyketide Inhibitors Targeting 3-dehydroquinate Dehydratase in the Shikimate Pathway of Enterococcus Faecalis PloS One. 2014 | Pubmed ID: 25072253 Loss of Quaternary Structure is Associated with Rapid Sequence Divergence in the OSBS Family Proceedings of the National Academy of Sciences of the United States of America. Jun, 2014 | Pubmed ID: 24872444 Glycine Decarboxylase is an Unusual Amino Acid Decarboxylase Involved in Tumorigenesis Biochemistry. Feb, 2014 | Pubmed ID: 24467211 Disruption of Biofilm Formation by the Human Pathogen Acinetobacter Baumannii Using Engineered Quorum-quenching Lactonases Antimicrobial Agents and Chemotherapy. 2014 | Pubmed ID: 24379199 Development of Quorum-based Anti-virulence Therapeutics Targeting Gram-negative Bacterial Pathogens International Journal of Molecular Sciences. 2013 | Pubmed ID: 23939429 Enhancing Gold Recovery from Electronic Waste Via Lixiviant Metabolic Engineering in Chromobacterium Violaceum Scientific Reports. 2013 | Pubmed ID: 23868689 Structural Evidence of a Productive Active Site Architecture for an Evolved Quorum-quenching GKL Lactonase Biochemistry. Mar, 2013 | Pubmed ID: 23461395 Establishing a Toolkit for Precursor-directed Polyketide Biosynthesis: Exploring Substrate Promiscuities of Acid-CoA Ligases Biochemistry. Jun, 2012 | Pubmed ID: 22587726 Directed Evolution of a Thermostable Quorum-quenching Lactonase from the Amidohydrolase Superfamily The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20980257 Site-directed Mutagenesis on Human Cystathionine-gamma-lyase Reveals Insights into the Modulation of H2S Production Journal of Molecular Biology. Feb, 2010 | Pubmed ID: 19961860 Directed Evolution of a Quorum-quenching Lactonase from Mycobacterium Avium Subsp. Paratuberculosis K-10 in the Amidohydrolase Superfamily Biochemistry. May, 2009 | Pubmed ID: 19374350 Evolution of Enzymatic Activities in the Enolase Superfamily: L-talarate/galactarate Dehydratase from Salmonella Typhimurium LT2 Biochemistry. Aug, 2007 | Pubmed ID: 17649980 Evolution of Enzymatic Activities in the Enolase Superfamily: D-tartrate Dehydratase from Bradyrhizobium Japonicum Biochemistry. Dec, 2006 | Pubmed ID: 17144653 Evolution of Enzymatic Activities in the Enolase Superfamily: L-fuconate Dehydratase from Xanthomonas Campestris Biochemistry. Dec, 2006 | Pubmed ID: 17144652 Evolution of Enzymatic Activities in the Enolase Superfamily: N-succinylamino Acid Racemase and a New Pathway for the Irreversible Conversion of D- to L-amino Acids Biochemistry. Apr, 2006 | Pubmed ID: 16584181 Evolution of Enzymatic Activities in the Orotidine 5'-monophosphate Decarboxylase Suprafamily: Structural Basis for Catalytic Promiscuity in Wild-type and Designed Mutants of 3-keto-L-gulonate 6-phosphate Decarboxylase Biochemistry. Feb, 2005 | Pubmed ID: 15697207 Evolution of Enzymatic Activities in the Orotidine 5'-monophosphate Decarboxylase Suprafamily: Enhancing the Promiscuous D-arabino-hex-3-ulose 6-phosphate Synthase Reaction Catalyzed by 3-keto-L-gulonate 6-phosphate Decarboxylase Biochemistry. Feb, 2005 | Pubmed ID: 15697206 Evolution of Enzymatic Activities in the Orotidine 5'-monophosphate Decarboxylase Suprafamily: Crystallographic Evidence for a Proton Relay System in the Active Site of 3-keto-L-gulonate 6-phosphate Decarboxylase Biochemistry. Jun, 2004 | Pubmed ID: 15157078 Evolution of Enzymatic Activities in the Orotidine 5'-monophosphate Decarboxylase Suprafamily: Mechanistic Evidence for a Proton Relay System in the Active Site of 3-keto-L-gulonate 6-phosphate Decarboxylase Biochemistry. Jun, 2004 | Pubmed ID: 15157077 Structural Evidence for a 1,2-enediolate Intermediate in the Reaction Catalyzed by 3-keto-L-gulonate 6-phosphate Decarboxylase, a Member of the Orotidine 5'-monophosphate Decarboxylase Suprafamily Biochemistry. Oct, 2003 | Pubmed ID: 14567674 Homologous (beta/alpha)8-barrel Enzymes That Catalyze Unrelated Reactions: Orotidine 5'-monophosphate Decarboxylase and 3-keto-L-gulonate 6-phosphate Decarboxylase Biochemistry. Mar, 2002 | Pubmed ID: 11900527 Utilization of L-ascorbate by Escherichia Coli K-12: Assignments of Functions to Products of the Yjf-sga and Yia-sgb Operons Journal of Bacteriology. Jan, 2002 | Pubmed ID: 11741871 Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases Song Buck Tay1,3, Jeng Yeong Chow2, Maybelle Kho Go1,3, Wen Shan Yew1,3 1Department of Biochemistry, Yong Loo Lin School of Medicine, 2Department of Chemistry, University of Utah, 3Synthetic Biology Research Consortium, National University of Singapore JoVE 53243 Immunology and Infection
Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases Song Buck Tay1,3, Jeng Yeong Chow2, Maybelle Kho Go1,3, Wen Shan Yew1,3 1Department of Biochemistry, Yong Loo Lin School of Medicine, 2Department of Chemistry, University of Utah, 3Synthetic Biology Research Consortium, National University of Singapore JoVE 53243 Immunology and Infection
