A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

October 20th, 2023

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Constructing the 3D Human-Stem-Cell-Derived In Vitro Blood Brain Barrier (Video) | JoVE

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Camille Goldman*^1,2,3,4,5, Natalie Suhy*^1,2,3,4,5, Jessica E. Schwarz^1,2,3,4,5, Emily Ruth Sartori^1,2,3,4,5, Rikki B. Rooklin^1,2,3,4,5, Braxton R. Schuldt^1,2,3,4,5, Louise A. Mesentier-Louro^1,2,3,4,5, Joel W. Blanchard^1,2,3,4,5

¹Icahn School of Medicine at Mount Sinai, ²Black Family Stem Cell Institute at Mount Sinai, ³Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, ⁴Friedman Brain Institute at Mount Sinai, ⁵Nash Family Department of Neuroscience at Mount Sinai

* These authors contributed equally

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يلعب الحاجز الدموي الدماغي (BBB) دورا حاسما في الحفاظ على بيئة دماغية مستقرة وصحية. يرتبط خلل BBB بالعديد من الأمراض العصبية. لقد قمنا بتطوير نموذج 3D ، مشتق من الخلايا الجذعية من BBB للتحقيق في أمراض الأوعية الدموية الدماغية ، وسلامة BBB ، وكيف يتم تغيير BBB عن طريق علم الوراثة والمرض.

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A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

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