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A 3D Blood-Brain Barrier Model Derived from Human Pluripotent Stem-Cells

October 20th, 2023
*1,2,3,4,5, *1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5, 1,2,3,4,5
1Icahn School of Medicine at Mount Sinai, 2Black Family Stem Cell Institute at Mount Sinai, 3Ronald M. Loeb Center for Alzheimer’s Disease at Mount Sinai, 4Friedman Brain Institute at Mount Sinai, 5Nash Family Department of Neuroscience at Mount Sinai
* These authors contributed equally

Summary
Automatic Translation

Blod-hjernebarrieren (BBB) har en avgjørende rolle i å opprettholde et stabilt og sunt hjernemiljø. BBB dysfunksjon er forbundet med mange nevrologiske sykdommer. Vi har utviklet en 3D, stamcelleavledet modell av BBB for å undersøke cerebrovaskulær patologi, BBB-integritet og hvordan BBB endres av genetikk og sykdom.

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