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JoVE Journal Cancer Research
Etablering og karakterisering av tre Afatinib-resistente Lung Adenokarsinom PC-9 Cell Lines utviklet med økende doser av Afatinib
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Etablering og karakterisering av tre Afatinib-resistente Lung Adenokarsinom PC-9 Cell Lines utviklet med økende doser av Afatinib

Article DOI: 10.3791/59473-v • 09:38 min • June 26th, 2019
June 26th, 2019 •
1, 1, 2, 1, 3
1Advanced Cancer Translational Research Institute, Showa University, 2Division of Breast Surgical Oncology, Department of Surgery, Showa University School of Medicine, 3Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine

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En metode for å etablere afatinib-motstand cellelinjer fra lunge adenokarsinom PC-9-celler ble utviklet, og resistente celler ble karakterisert. De resistente cellene kan brukes til å undersøke epidermal vekstfaktorreseptor tyrosin kinase hemmer-motstand mekanismer, gjelder for pasienter med ikke-liten celle lungekreft.

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Kreftforskning trinnvis dose eskalering resistens EGFR-aktivering mutasjoner EGFR-TKI afatinib lungekreft
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