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JoVE Journal Medicine
En Murine Model af fostereksponering for mødrebetændelse for at studere virkningerne af akut chorioamnionitis på nyfødte tarm udvikling
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En Murine Model af fostereksponering for mødrebetændelse for at studere virkningerne af akut chorioamnionitis på nyfødte tarm udvikling

Article DOI: 10.3791/61464-v • 08:50 min • June 24th, 2020
June 24th, 2020 •
1, 1, 2, 1, 3, 1,4
1Division of Neonatology, Stead Family Department of Pediatrics, University of Iowa, 2Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Iowa, 3Division of Neonatology, Department of Pediatrics, Vanderbilt University, 4Department of Microbiology & Immunology, University of Iowa

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Vi udviklede en model af chorioamnionitis at simulere fostereksponering for moderens inflammation (FEMI) uden komplikationer af levende organismer til at undersøge virkningerne af FEMI på udviklingen af afkom tarmkanalen. Dette giver mulighed for undersøgelse af mekanistiske årsager til udvikling af tarmskade efter chorioamnionitis.

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Denne måned i JoVE Lipopolysaccharide (LPS) Føtal eksponering for moderens inflammation (FEMI) Chorioamnionitis Tarm udvikling Paneth celle Goblet celle
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