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Journal / Neuroscience / Moleculaire modulatie door lentivirus-geleverde…
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Moleculaire modulatie door lentivirus-geleverde specifieke shRNA's in endoplasmatisch reticulum gestreste neuronen
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Moleculaire modulatie door lentivirus-geleverde specifieke shRNA's in endoplasmatisch reticulum gestreste neuronen

Article DOI: 10.3791/61974-v • 10:50 min • April 24th, 2021
April 24th, 2021 •
1, 1, 1
1Instituto de Investigación Médica M y M Ferreyra, INIMEC-CONICET, Universidad Nacional de Córdoba

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In de huidige studie wordt de expressie neergehaald van twee stroomafwaartse signaalcomponenten van de PERK-route, de cytoprotectieve calcineurine en de pro-apoptotische CHOP, door specifieke shRNA's te gebruiken. Op tegenovergestelde manieren moduleren deze de gevoeligheid van primaire corticale neuronen voor neurietatrofie na inductie van endoplasmatische reticulumstress.

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Neuroscience Neurodegeneratieve aandoeningen Unfolded protein response (UPR) Protein kinase RNA [PKR]-like ER kinase (PERK) Ganglioside GM2 Calcineurin (CN) CHOP (CCAAT/enhancer binding protein homologous protein) Microtubule-associated protein 2 (MAP2)
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