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JoVE Journal Neuroscience
Molekylær modulering av lentivirus-leverte spesifikke shRNA i endoplasmatiske retikulumstressede nevroner
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Molekylær modulering av lentivirus-leverte spesifikke shRNA i endoplasmatiske retikulumstressede nevroner

Article DOI: 10.3791/61974-v • 10:50 min • April 24th, 2021
April 24th, 2021 •
1, 1, 1
1Instituto de Investigación Médica M y M Ferreyra, INIMEC-CONICET, Universidad Nacional de Córdoba

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I denne studien blir uttrykket slått ned av to nedstrøms signalkomponenter i PERK-banen, det cytoprotektive kalsineurinet og det pro-apoptotiske CHOP, ved å bruke spesifikke shRNAer. På motsatte måter modulerer disse følsomheten til primære kortikale nevroner for neurittatrofi etter induksjon av endoplasmatisk retikulumstress.

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Nevrovitenskap utgave 170 Nevrodegenerative lidelser Ufoldet proteinrespons (UPR) Proteinkinase RNA [PKR]-lignende ER-kinase (PERK) Gangliosid GM2 Calcineurin (CN) CHOP (CCAAT/enhancer binding protein homologt protein) Mikrotubuli-assosiert protein 2 (MAP2)
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