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JoVE Journal Neuroscience
Le modèle de rat 6-hydroxydopamine de la maladie de Parkinson
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Le modèle de rat 6-hydroxydopamine de la maladie de Parkinson

Article DOI: 10.3791/62923-v • 08:10 min • October 27th, 2021
October 27th, 2021 •
1, 1, 1, 1, 1, 1
1Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo

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Le modèle de la 6-hydroxydopamine (6-OHDA) est utilisé depuis des décennies pour faire progresser la compréhension de la maladie de Parkinson. Dans ce protocole, nous montrons comment effectuer des lésions nigrostriatales unilatérales chez le rat en injectant du 6-OHDA dans le faisceau médian du cerveau antérieur, évaluer les déficits moteurs et prédire les lésions à l’aide du test de pas.

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Neurosciences numéro 176
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