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Journal / Bioengineering / Subretinale implantatie van RPE op een drager in…
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Subretinale implantatie van RPE op een drager in minivarkens
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Subretinale implantatie van RPE op een drager in minivarkens: richtlijnen voor preoperatieve preparaten, chirurgische technieken en postoperatieve zorg

Article DOI: 10.3791/63505-v • 11:06 min • November 11th, 2022
November 11th, 2022 •
*1,2, *3, 4, 4, 4, 5,6, 5,6, 5,6, 5,6, 5,6, 5, 5, 5, 5, 7, 8, 9, 10, 11, 1, 1, 5, *8, *5
1Eye Clinic, Department of Ophthalmology, University Hospital Giessen and Marburg GmbH, 2Karl Landsteiner Institute for Retinal Research and Imaging, 3Department of Ophthalmology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, 4Institute of Macromolecular Chemistry, Czech Academy of Sciences, 5Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 6Department of Cell Biology, Faculty of Science, Charles University, 7Institute of Experimental Medicine, Czech Academy of Sciences, 8Center for Eye Research, Department of Ophthalmology, Oslo University Hospital and Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 9Moorfields Eye Hospitals UAE, 10Stem Cell Therapies in Neurodegenerative Diseases Lab, Research Center “Principe Felipe”, 11Eye Center Donaustadt, Department of Ophthalmology, Sigmund Freud University
* These authors contributed equally

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De subretinale implantatie van retinaal gepigmenteerd epitheel (RPE) is een van de meest veelbelovende benaderingen voor de behandeling van degeneratieve retinale ziekten. De uitvoering van preklinische studies op diermodellen met grote ogen blijft echter een uitdaging. Dit rapport presenteert richtlijnen voor de subretinale transplantatie van RPE op een celdrager in minivarkens.

Tags

Bioengineering Age-related macular degeneration retinal pigmented epitheel RPE large-eye animal model minipigs pars plana vitrectomy PPV cell carrier in vivo surgery preoperatieve en postoperatieve zorg
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