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Journal / Bioengineering / Minipiglerde RPE'nin taşıyıcı üzerine subretinal…
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Minipiglerde RPE'nin taşıyıcı üzerine subretinal implantasyonu
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Minipiglerde RPE'nin taşıyıcı üzerine subretinal implantasyonu: Preoperatif preparatlar, cerrahi teknikler ve postoperatif bakım için kılavuzlar

Article DOI: 10.3791/63505-v • 11:06 min • November 11th, 2022
November 11th, 2022 •
*1,2, *3, 4, 4, 4, 5,6, 5,6, 5,6, 5,6, 5,6, 5, 5, 5, 5, 7, 8, 9, 10, 11, 1, 1, 5, *8, *5
1Eye Clinic, Department of Ophthalmology, University Hospital Giessen and Marburg GmbH, 2Karl Landsteiner Institute for Retinal Research and Imaging, 3Department of Ophthalmology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, 4Institute of Macromolecular Chemistry, Czech Academy of Sciences, 5Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 6Department of Cell Biology, Faculty of Science, Charles University, 7Institute of Experimental Medicine, Czech Academy of Sciences, 8Center for Eye Research, Department of Ophthalmology, Oslo University Hospital and Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 9Moorfields Eye Hospitals UAE, 10Stem Cell Therapies in Neurodegenerative Diseases Lab, Research Center “Principe Felipe”, 11Eye Center Donaustadt, Department of Ophthalmology, Sigmund Freud University
* These authors contributed equally

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Retina pigmentli epitelin (RPE) subretinal implantasyonu, dejeneratif retina hastalıklarının tedavisinde en umut verici yaklaşımlardan biridir. Bununla birlikte, büyük gözlü hayvan modelleri üzerinde yapılan klinik öncesi çalışmaların performansı zorlu olmaya devam etmektedir. Bu yazıda RPE'nin bir hücre taşıyıcısı üzerinde minidomuzlara subretinal transplantasyonu için kılavuzlar sunulmaktadır.

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Biyomühendislik Sayı 189 Yaşa bağlı makula dejenerasyonu retina pigmentli epitel RPE büyük gözlü hayvan modeli minidomuzlar pars plana vitrektomi PPV hücre taşıyıcı in vivo cerrahi preoperatif ve postoperatif bakım
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