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Journal / Genetics / Исследование патогенеза мутации MYH7 Gly823Glu…
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Genetics

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JoVE Journal Genetics
Исследование патогенеза мутации MYH7 Gly823Glu при семейной гипертрофической кардиомиопатии с использованием мышиной модели
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
Journal (Genetics)
A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
 
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Исследование патогенеза мутации MYH7 Gly823Glu при семейной гипертрофической кардиомиопатии с использованием мышиной модели

Article DOI: 10.3791/63949-v • 03:45 min • August 8th, 2022
August 8th, 2022 •
*1,2, *3, 4, 4, 1,2, 1,2, 1,2, 2,5, 4, 1,2
1Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 2The Second Clinical College of Guangzhou University of Chinese Medicine, 3Department of Cardiovascular Surgery, The First Affiliated Hospital, Jinan University, 4Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, 5Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine
* These authors contributed equally

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Основываясь на семействе семейных наследственных кардиомиопатий, найденных в нашей клинической работе, мы создали модель мыши C57BL / 6N с точечной мутацией (G823E) в локусе MYH7 мыши с помощью CRISPR / Cas9-опосредованной геномной инженерии для проверки этой мутации.

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