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JoVE Journal Cancer Research
Testa cancerimmunotherapeutics i en humaniserad musmodell som bär mänskliga tumörer
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Testa cancerimmunotherapeutics i en humaniserad musmodell som bär mänskliga tumörer

Article DOI: 10.3791/64606-v • 15:24 min • December 16th, 2022
December 16th, 2022 •
*1, *1, 1, 1, 2, 2, 3, 1, 2, 1
1Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver Anschutz Medical Campus, 2Division of Oncology, School of Medicine, University of Colorado Denver Anschutz Medical Campus, 3Department of Medical Oncology, Catalan Institute of Oncology (ICO-L'Hospitalet)
* These authors contributed equally

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Detta protokoll beskriver genereringen av möss med humant immunsystem (HIS) för immunonkologistudier. Instruktioner och överväganden vid användning av denna modell för testning av humana immunotherapeutics på humana tumörer implanterade i denna modell presenteras med tonvikt på att karakterisera det mänskliga immunsystemets svar på tumören.

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Cancerforskning nr 190
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