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Journal / Medicine / Bruk av nikotin i en silika-eksponert musemodell…
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JoVE Journal Medicine
Bruk av nikotin i en silika-eksponert musemodell for å fremme lungeepitelial-mesenkymal overgang
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Bruk av nikotin i en silika-eksponert musemodell for å fremme lungeepitelial-mesenkymal overgang

Article DOI: 10.3791/65127-v • 06:12 min • March 3rd, 2023
March 3rd, 2023 •
*1,2,3,4, *1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4
1Key Laboratory of Industrial Dust Control and Occupational Health of the Ministry of Education, Anhui University of Science and Technology, 2Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Anhui University of Science and Technology, 3Anhui Province Engineering Laboratory of Occupational Health and Safety, 4School of Medicine, Department of Medical Frontier Experimental Center, Anhui University of Science and Technology
* These authors contributed equally

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Denne studien beskriver en musemodell for å studere den synergistiske effekten av nikotin på utviklingen av lungefibrose i eksperimentelle silikosemus. Musemodellen med dobbel eksponering simulerer den patologiske progresjonen i lungen etter samtidig eksponering for nikotin og silika. Metodene som beskrives er enkle og svært reproduserbare.

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Nikotin silika lungeepitel-mesenkymal overgang silikose musemodell kronisk nikotininntak gjentatt eksponering for silika lungefibrose sigarettrøyk subkutan injeksjon krystallinsk silikapulver inhalasjonseksponering dobbelteksponert musemodell
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