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Uso de Nicotina em Modelo de Camundongo Exposto à Sílica para Promover a Transição Epitélio-Mesenquimal Pulmonar
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Uso de Nicotina em Modelo de Camundongo Exposto à Sílica para Promover a Transição Epitélio-Mesenquimal Pulmonar

Article DOI: 10.3791/65127-v • 06:12 min • March 3rd, 2023
March 3rd, 2023 •
*1,2,3,4, *1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4
1Key Laboratory of Industrial Dust Control and Occupational Health of the Ministry of Education, Anhui University of Science and Technology, 2Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Anhui University of Science and Technology, 3Anhui Province Engineering Laboratory of Occupational Health and Safety, 4School of Medicine, Department of Medical Frontier Experimental Center, Anhui University of Science and Technology
* These authors contributed equally

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Este estudo descreve um modelo murino para estudar o efeito sinérgico da nicotina na progressão da fibrose pulmonar em camundongos silicose experimentais. O modelo de camundongo de dupla exposição simula a progressão patológica no pulmão após exposição simultânea à nicotina e à sílica. Os métodos descritos são simples e altamente reprodutíveis.

Tags

Nicotina Sílica Transição Epitélio-mesenquimal Pulmonar Silicose Modelo de Camundongo Ingestão Crônica de Nicotina Exposição Repetida à Sílica Fibrose Pulmonar Fumaça de Cigarro Injeção Subcutânea Sílica Cristalina em Pó Exposição por Inalação Modelo de Camundongo Duplamente Exposto
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