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JoVE Journal Chemistry
En arbejdsgang for lipidnanopartikelformuleringsoptimering (LNP) ved hjælp af designede blandingsproceseksperimenter og selvvaliderede ensemblemodeller (SVEM)
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En arbejdsgang for lipidnanopartikelformuleringsoptimering (LNP) ved hjælp af designede blandingsproceseksperimenter og selvvaliderede ensemblemodeller (SVEM)

Article DOI: 10.3791/65200-v • 13:54 min • August 18th, 2023
August 18th, 2023 •
1, 2, 1, 1
1Adsurgo, LLC, 2Arcturus Therapeutics

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Denne protokol giver en tilgang til formuleringsoptimering over blandings-, kontinuerlige og kategoriske undersøgelsesfaktorer, der minimerer subjektive valg i den eksperimentelle designkonstruktion. Til analysefasen anvendes en effektiv og brugervenlig modelleringstilpasningsprocedure.

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Denne måned i JoVE nummer 198
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