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Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model
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Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

DOI:
10.3791/55845-v

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09:57 min

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June 04, 2017

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, , ,
1Department of Neurological Surgery, Feinberg School of Medicine,Northwestern University

Chapters

  • 00:05Title
  • 01:04Intracranial Implantantion and Whole Brain Irradiation
  • 04:16Human Neural Stem Cell (NSC) Modification and Intranasal Delivery
  • 07:14Results: Representative hNSC Modifications and Analyses
  • 08:53Conclusion

Summary

Automatic Translation

Automatic Translation

Stem cells are promising therapeutic carriers to treat brain tumors due to their intrinsic tumor tropism. Non-invasive intranasal stem cell delivery bypasses the blood brain barrier and demonstrates strong potential for clinical translation. This article summarizes the basic principles of intranasal stem cell delivery in a mouse model of glioma.

Tags

Intranasal DeliveryTherapeutic Stem CellsGlioblastomaMouse ModelPreclinicalBrain TumorBlood-brain BarrierBrain MalignanciesBrain DisordersGlioma CellsCell CultureTrypsinPBSCell SuspensionCentrifugationSterile SalineStereotaxic FrameHamilton Micro-syringeBurr HoleDura Surface

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