Chronic Infusion Model
Chronic Infusion Model - Related Videos
08:18
A Model of Chronic Nutrient Infusion in the Rat
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Cited by 1 •
2013
A protocol for chronic infusions of glucose and Intralipid in rats is described. This model can be used to study the impact of nutrient excess on organ function and physiological parameters.
10:19
Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
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Cited by 11 •
2016
To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.
06:28
An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
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2025
The present protocol describes a novel approach to modeling chronic obstructive pancreatitis, which involves visualization of the pancreatic duct and electrocoagulation of the pancreatic duct to cause pancreatic duct obstruction.
06:44
A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
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Cited by 1 •
2021
Chronic pancreatitis (CP) is a disease characterized by inflammation and fibrosis of the pancreas, often associated with intractable abdominal pain. This article focuses on refining the technique to generate a mouse model of CP via bile duct infusion with 2,4,6 -trinitrobenzene sulfonic acid (TNBS).
09:01
Chronic Salmonella Infected Mouse Model
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Cited by 12 •
2010
Establish a chronic bacterial infected mouse model with persistent Salmonella typhimurium colonization in intestine for 27 weeks.
FAQs
Its main advantage is sustained exposure rather than a brief treatment episode. Continuous or repeated delivery can reduce the fluctuations associated with short-term administration, helping investigators observe behavioral adaptations that emerge over time. This distinction is important when studying prolonged effects on activity, learning, motivation, anxiety-like responses, or dependence-related behaviors.
The catheter or cannula provides a connection for delivering the selected substance into the organism, while the infusion pump controls the timing and amount of delivery. Together, these components support a controlled exposure pattern and reduce the need for repeated handling, making it possible to examine behavior during an extended treatment period.
Extended exposure can reveal changes that may not appear after a single or short-term administration. In behavioral research, this allows investigators to examine how organisms adjust to sustained drug, hormone, or other biologically active compound exposure. The resulting observations may clarify long-term changes in activity, learning, motivation, anxiety-like responses, or dependence-related behavior.
A typical setup uses an implanted catheter or cannula connected to an infusion pump, followed by controlled delivery of the selected substance over an extended period. Researchers then evaluate behavioral outcomes relevant to the study, such as activity, learning, motivation, anxiety-like responses, or dependence-related behaviors, rather than relying only on short-term observations.
Minimizing repeated handling helps separate behavioral effects associated with the infused substance from effects linked to frequent intervention during treatment. The pump-based arrangement also supports more consistent exposure than repeated handling-dependent administration. Consequently, observed changes in behavior can be examined in the context of sustained treatment with fewer exposure fluctuations.
This approach is useful when the research question concerns long-term treatment, prolonged exposure, or behavioral adaptation rather than an immediate response. It can be applied to studies of drugs, hormones, and other biologically active compounds, with outcomes including activity, learning, motivation, anxiety-like responses, and dependence-related behaviors.