Journal
/
Medicine
/
A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
JoVE Journal
Medicine
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Medicine
A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

DOI:
10.3791/62080-v

•

06:44 min

•

February 28, 2021

•

, , , , ,
1Department of Surgery,Medical University of South Carolina, 2Ralph H. Johnson Veterans Affairs Medical Center

Chapters

  • 00:04Introduction
  • 00:52Mouse Monitoring and Surgery
  • 04:03Results: Representative Effect of Bile Duct TNBS Infusion in a Mouse Chronic Pancreatitis Model
  • 05:48Conclusion

Summary

Automatic Translation

Automatic Translation

Chronic pancreatitis (CP) is a disease characterized by inflammation and fibrosis of the pancreas, often associated with intractable abdominal pain. This article focuses on refining the technique to generate a mouse model of CP via bile duct infusion with 2,4,6 -trinitrobenzene sulfonic acid (TNBS).

Tags

Mouse ModelChronic PancreatitisBile DuctTNBS InfusionNeuropathic PainVon Frey MonofilamentsTNBS SolutionPancreatic DuctAbdominal PainFibrosisInflammation

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

Cannulation of the Mouse Submandibular Salivary Gland via the Wharton’s Duct

3-Dimensional Resin Casting and Imaging of Mouse Portal Vein or Intrahepatic Bile Duct System

A Model of Chronic Nutrient Infusion in the Rat

A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography

Read Article