Infraorbital Nerve Injury
Infraorbital Nerve Injury - Related Videos
10:52
Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain
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Cited by 45 •
2015
This manuscript describes a rodent model to study trigeminal neuropathic pain. The methods described include surgical procedures to perform a chronic constriction injury of the rat’s infraorbital nerve and the post-surgical behavioral tests to measure the changes in spontaneous and evoked behavior that are indicative of persistent pain and allodynia.
02:02
Inducing Orofacial Neuropathic Pain in a Rat Model via Infraorbital Nerve Ligations
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2025
This video demonstrates the induction of orofacial neuropathic pain in a rat model by ligating the infraorbital nerve. This results in nerve damage and inflammation, causing abnormal pain signaling and mimicking chronic pain conditions, which can be used to study the orofacial pain assay.
04:39
Induction of Neuropathic Pain in a Rat Model by Constriction of the Infraorbital Nerve
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2025
Source: Deseure, K., et al. Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain. J. Vis. Exp. (2015).This video demonstrates a method to induce neuropathic pain in a rat model by constricting the infraorbital nerve. After exposing the infraorbital nerve and tying ligatures to constrict it, the immune response at the injury site increases the excitability of neighboring neurons, which transmit pain signals to the brain.
03:34
Inducing a Facial Nerve Injury in a Rat Model
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2025
This video demonstrates a surgical protocol on a rat model, detailing steps from anesthesia preparation to facial nerve injury induction. This protocol is useful for studying nerve regeneration and surgical techniques in medical research.
05:38
Chronic Constriction Injury of the Distal Infraorbital Nerve (DIoN-CCI) in Mice to Study Trigeminal Neuropathic Pain
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Cited by 7 •
2024
Chronic constriction injury of the distal infraorbital nerve in mice induces changes in spontaneous behavior (increased face grooming activity) and nocifensive behavior in response to tactile stimulation (hyperresponsiveness to von Frey hair stimulation) that are signs of ongoing pain and allodynia and serves as a model for trigeminal neuropathic pain.
FAQs
The resulting sensory experience depends on how touch, temperature, and pain signaling is affected. Some individuals or experimental subjects may show reduced sensation, while others develop tingling, hypersensitivity, or neuropathic pain. These contrasting outcomes matter because a diminished response to contact and an exaggerated response to contact can produce very different behavioral patterns.
Facial sensory signals help shape how subjects respond to contact with the cheek, upper lip, lateral nose, and lower eyelid. After injury, altered signaling can change reactions to touch or produce pain-related behavior that is not explained by motivation alone. Behavioral observations therefore provide information about sensory disturbance as well as the subject’s immediate response.
The infraorbital nerve is a branch of the trigeminal nerve, so its injury provides a focused way to examine trigeminal sensory damage. Researchers can relate changes in facial sensation to pain-related behavior and sensory recovery. This connection also places local facial symptoms within the broader scientific study of trigeminal nerve function and injury.
Changes may appear in feeding, grooming, facial exploration, or responses to touch. For example, altered sensation or neuropathic pain may affect how a subject interacts with food, attends to the face, explores its surroundings, or reacts when the affected region is contacted. These behaviors are useful observations because they connect sensory disturbance with everyday functional activity.
Experimental models allow researchers to assess pain-related behavior and examine how sensory function changes after trigeminal nerve damage. They can also support studies of sensory recovery over time and provide a context for evaluating treatments. The behavioral component is important because it shows how nerve injury may affect observable responses rather than only sensory signaling itself.
Researchers can investigate the presence of pain-related behavior, changes in responses to touch, and the course of sensory recovery. The model also supports evaluation of treatments intended for trigeminal nerve damage. In behavioral studies, feeding, grooming, facial exploration, and touch responses offer complementary outcomes for examining how altered facial sensation affects activity and interaction.