Arteriovenous Closed Circuit
Arteriovenous Closed Circuit - Related Videos
10:10
A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail
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Cited by 24 •
2016
Here we present a murine model of arteriovenous fistula (AVF) failure in which a clinically relevant anastomotic configuration is incorporated. This model can be used to study the pathophysiology and to test possible therapeutic interventions.
07:25
Open Surgical Resection of Cerebral Arteriovenous Malformations
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2025
Source: Rennert, R. C., et al. Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations. J. Vis. Exp. (2017).This video demonstrates the open surgical resection of a cerebral arteriovenous malformation (AVM) in a human brain. The procedure involves creating a bone flap, accessing the subarachnoid space, identifying and occluding feeding arteries and draining veins, and carefully removing the AVM. Intraoperative angiography confirms complete resection,...
14:58
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
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Cited by 4 •
2017
Surgery is the gold standard for accessible arteriovenious malformations (AVMs), and pre-operative embolization can simplify this procedure. We describe our approach for staged endovascular embolization and open resection of AVMs, and provide a representative clinical example highlighting the advantages of a comprehensively trained neurovascular surgeon leading a multi-disciplinary clinical team.
05:53
Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
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Cited by 5 •
2016
After puncturing the aorta through the inferior vena cava (IVC) to create an aorto-caval fistula in the mouse, solution containing a drug is infused into the IVC via the same needle, followed by incubation. This method enables more robust drug delivery to the venous endothelium compared to the external route.
05:27
Establishing In Situ Closed Circuit Perfusion of Lower Abdominal Organs and Hind Limbs in Mice
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2020
A protocol is described for in situ perfusion of the mouse lower body, including the bladder, the prostate, sex organs, bone, muscle and foot skin.
FAQs
Flow and pressure are governed by the pump and by the position of the test construct between the arterial and venous sides. Fluid moves through the construct before returning to the venous pathway, so researchers can regulate perfusion conditions while maintaining recirculation. This arrangement supports examination of transport processes under controlled, physiologically relevant flow.
A closed loop limits fluid loss because the same fluid recirculates through the system. It also supports repeated sampling and ongoing monitoring while the tissue, organ, or engineered device remains under perfusion. These features help bioengineers compare responses under controlled conditions and maintain an experimental environment that supports continuous circulation.
The arterial and venous sides establish the direction of circulation, while the intervening construct provides the site where flow, pressure, and transport can be examined. The pump maintains movement through this pathway and returns fluid to the venous side. Together, these components let investigators connect perfusion conditions with the behavior of the tested tissue or device.
A typical setup begins by connecting the arterial and venous pathways to the tissue, organ, or engineered device under study. Researchers then operate a pump to drive fluid through the construct, return it to the venous side, and regulate relevant conditions. Sampling or monitoring can be performed during recirculation, allowing repeated observations within one experiment.
Arteriovenous closed circuits support vascular and tissue-engineering studies, organ perfusion models, and testing of biomaterials or medical devices. Their use is appropriate when research requires a perfused tissue or organ model, an engineered construct, or a device evaluated under circulating conditions. The loop provides a controlled setting for observing function and response.
In bioengineering, the system can show how a construct or device behaves under controlled circulation. Researchers can monitor function, response, and transport-related behavior while adjusting perfusion conditions and collecting samples. This information helps evaluate engineered tissues, biomaterials, and medical devices within a repeatable experimental environment that preserves continuous fluid movement.