Automated Synthesis
Automated Synthesis - Related Videos
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11:03
Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
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Cited by 6 •
2017
We demonstrate the semi-automated radiochemical synthesis of [18F]3F4AP and quality control procedures.
08:24
Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
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Cited by 5 •
2008
The Ugi reaction has proved to be a convenient way to quickly create diverse libraries of compounds. It involves the reaction of an amine, an aldehyde, a carboxylic acid and an isonitrile typically in methanol at room temperature. In this video, we utilize a 48-slot Mettler-Toledo MiniBlock equipped with filtration tubes and a Mettler-Toledo MiniMapper automated liquid handler was used to deliver the reagents and solvent. The parameters of interest were the concentration, the solvent...
09:42
Solid Phase Synthesis
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2023
Source: Vy M. Dong and Diane Le, Department of Chemistry, University of California, Irvine, CA Merrifield's solid-phase synthesis is a Nobel Prize winning invention where a reactant molecule is bound on a solid support and undergoes successive chemical reactions to form a desired compound. When the molecules are bound to a solid support, excess reagents and byproducts can be removed by washing away the impurities, while the target compound remains bound to the resin. Specifically, we will...
08:33
Hydrogel Synthesis
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2023
Source: Amber N. Barron, Ashlea Patterson, and Taylor D. Sparks, Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT Hydrogels are a versatile class of cross-linked polymers produced through relatively simple procedures and with generally inexpensive materials. They can be formed from solution and involve a polymer backbone formed from monomer reagents, an initiator which makes the polymer reactive and a crosslinking species which binds the polymer chains...
14:37
High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
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Cited by 7 •
2012
In this article, a high throughput method is presented for the synthesis of oligosaccharides and their attachment to the surface of polyanhydride nanoparticles for further use in targeting specific receptors on antigen presenting cells.
FAQs
A programmed workflow links reagent dispensing, mixing, reaction timing, and temperature control in a defined sequence. Depending on the system, purification and in-process monitoring can also be incorporated. Coordinating these stages helps maintain consistent operating conditions across runs, which is especially useful when researchers need to compare engineered molecules or evaluate many designs systematically.
Reagent delivery, mixing, reaction duration, and temperature are central variables because the instrument manages each according to the programmed workflow. Consistent control of these conditions reduces differences caused by manual handling. When multiple reactions are performed in parallel, standardized settings make it easier to distinguish design-related effects from variation introduced during preparation.
Parallel experimentation allows researchers to prepare and compare multiple molecular or material designs within a coordinated workflow. This capability supports systematic testing rather than relying on isolated trials. In bioengineering, it can accelerate evaluation of peptides, nucleic acids, biomaterials, and other engineered molecules for assay development, drug research, diagnostics, or tissue-engineering studies.
The main difference is how much of the workflow depends on direct operator intervention. Automated systems carry out programmed dispensing, mixing, timing, and temperature control with limited manual involvement, whereas manual preparation requires the operator to perform more of these stages. Reduced operator variability can improve consistency and help a promising process move toward reproducible production.
A workflow begins with a defined sequence that specifies how reagents are dispensed and combined. The system then manages reaction timing and temperature control, while optional stages may include purification or in-process monitoring. Researchers can use the resulting coordinated process to prepare target molecules or materials under repeatable conditions and to compare outcomes across multiple runs.
Applications include preparing peptides, nucleic acids, biomaterials, and other engineered molecules. These products can support assay development, drug research, diagnostics, and tissue engineering. The same approach also helps connect early design testing with manufacturing goals because consistent, programmable workflows provide a basis for evaluating processes before scaling promising preparations toward reproducible production.