Biocompatible Surgical Adhesive
Biocompatible Surgical Adhesive - Related Videos
03:47
Implantation of a Flexible Biocompatible Probe in a Glioblastoma Mouse Model
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2025
Source: Lefevre, M. C., et al., Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma. J. Vis. Exp. (2022)This video demonstrates the implantation of a flexible, biocompatible probe in a glioblastoma mouse model to deliver targeted pulsed electric field therapy for neurotherapeutic applications.
06:32
A Chitosan Based, Laser Activated Thin Film Surgical Adhesive, 'SurgiLux': Preparation and Demonstration
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Cited by 32 •
2012
The fabrication of a novel, flexible thin film surgical adhesive from FDA approved ingredients, chitosan and indocyanine green is described. Bonding of this adhesive to collagenous tissue through a simple activation process with a low-powered infra-red laser is demonstrated.
01:14
Adhesion
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2019
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules. Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
06:40
Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
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Cited by 99 •
2013
Insertion of flexible neural microelectrode probes is enabled by attaching probes to rigid stiffeners with polyethylene glycol (PEG). A unique assembly process ensures uniform and repeatable attachment. After insertion into tissue, the PEG dissolves and the stiffener is extracted. An in vitro test method evaluates the technique in agarose gel.
07:40
Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
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Cited by 3 •
2016
This flow adhesion assay provides a simple, high impact model of T cell-epithelial cell interactions. A syringe pump is used to generate shear stress, and confocal microscopy captures images for quantification. The goal of these studies is to effectively quantify T cell adhesion using flow conditions.
FAQs
The bonding layer develops through polymerization or crosslinking after application. These processes convert the applied material into a cohesive layer that can remain attached across a tissue or device interface. In bioengineering, controlling this transition is important because the resulting structure must balance adhesion with tissue compatibility and healing requirements.
Conformity allows the adhesive layer to contact uneven tissue surfaces rather than relying only on rigid, localized attachment points. A cohesive layer that adapts to these surfaces can support sealing and help create a barrier against fluid leakage. This property is especially relevant when tissue geometry makes conventional closure approaches less suitable.
Key variables include adhesion strength, curing conditions, biodegradability, and compatibility with tissue healing. Adhesion strength affects whether the material remains attached, while curing conditions influence formation of the cohesive layer. Biodegradability and healing compatibility determine how the material fits within the tissue-repair process, making these factors central to material design.
Adhesives can reduce the need for sutures or staples by forming a continuous bonded layer over or between tissue surfaces. This approach may support wound closure, sealing, or hemostasis while conforming to moist and irregular structures. The appropriate choice depends on the required adhesion strength, curing conditions, and compatibility with surrounding tissue and healing.
Following application, polymerization or crosslinking forms the adhesive's cohesive layer. That layer can bond tissue or a device, conform to irregular surfaces, and provide a barrier against fluid leakage. In practical use, the material's outcome depends on whether its curing conditions, adhesion strength, biodegradability, and tissue compatibility match the intended surgical role.
Supported uses include wound closure, hemostasis, sealing incisions, and attaching implants. They may also help limit fluid leakage by creating a barrier at the treated interface. Because each task places different demands on adhesion, curing, and interaction with healing tissue, bioengineers design materials around the specific closure, sealing, or attachment requirement.
Bioengineering connects material properties with surgical performance and tissue healing. Designers must coordinate bonding behavior, curing conditions, biodegradability, and compatibility with surrounding structures rather than optimizing adhesion strength alone. This integrated approach supports development of adhesives that can perform closure, sealing, hemostatic, or implant-attachment functions while minimizing toxicity, inflammation, and damage to nearby tissue.