Sensor Chip
Sensor Chip - Related Videos
05:21
Surface Plasmon Resonance to Study Biomolecular Interactions Using a Sensor Chip
0 Views •
2025
This video describes the surface plasmon resonance, or SPR, technique for studying the interaction between two molecules using a sensor chip. The change in resonance angle and the intensity of the reflected light are detected as a function of the association and dissociation of two molecules, and this provides information about the interactions between the two molecules.
09:30
Bacterial Detection & Identification Using Electrochemical Sensors
0 Views •
Cited by 6 •
2013
We describe an electrochemical sensor assay method for rapid bacterial detection and identification. The assay involves a sensor array functionalized with DNA oligonucleotide capture probes for ribosomal RNA (rRNA) species-specific sequences. Sandwich hybridization of target rRNA with the capture probe and a horseradish peroxidase-linked DNA oligonucleotide detector probe produces a measurable amperometric current.
11:23
Lensless Fluorescent Microscopy on a Chip
0 Views •
Cited by 8 •
2011
A lensless on-chip fluorescent microscopy platform is demonstrated that can image fluorescent objects over an ultra-wide field-of-view of e.g., >0.6-8 cm2 with <4μm resolution using a compressive sampling based decoding algorithm. Such a compact and wide-field fluorescent on-chip imaging modality could be valuable for high-throughput cytometry, rare-cell research and microarray-analysis.
09:14
Glovebox and Impurity Sensors
0 Views •
2023
Source: Tamara M. Powers, Department of Chemistry, Texas A&M University The glovebox provides a straightforward means to handle air- and moisture-sensitive solids and liquids. The glovebox is what it sounds like: a box with gloves attached to one or more sides, which allows the user to perform manipulations within the glovebox under an inert atmosphere. For manipulations under inert atmospheres, chemists can choose between Schlenk or high-vacuum techniques and a glovebox. Schlenk and...
07:50
Chip-Based Digital PCR to Detect Rare Transcript Variants Using a Nanofluidic Chip
0 Views •
2025
This video demonstrates chip-based digital PCR — a variation of the digital PCR technique that is useful in detecting rare transcript variants. The PCR reaction is partitioned into the chambers of a nanofluidic chip, each of which acts as an independent reaction. The detection of fluorescence signals from the chambers with amplified targets confirms the presence of rare transcript variants in the sample.
FAQs
The recognition element and transducer perform complementary tasks. An enzyme, antibody, nucleic acid probe, or living cell first interacts with the target, establishing the biologically relevant event. The transducer then converts that event into an electrical, optical, or mechanical response, and circuits process the resulting signal. This separation connects biological selectivity with electronic measurement.
It provides the biological interface that responds to the substance or condition being measured. Different elements support different sensing targets: enzymes, antibodies, nucleic acid probes, and living cells are all identified as possible choices. Selecting among them therefore links the chip's measurement to the biological interaction of interest, while the transducer handles signal conversion.
These options differ primarily in the form of the output delivered for processing. An electrical response produces an electronic measurement, whereas optical and mechanical responses provide other measurable signal formats. The appropriate choice depends on how the recognition event will be converted and processed in the intended sensor system, rather than on a universally superior transduction mode.
A simplified workflow begins when a sample or monitored condition is presented to the chip. The recognition element interacts with the relevant target, the transducer converts that interaction into a measurable response, and circuits process the signal. In a lab-on-a-chip or biosensor format, this sequence compresses biological detection and signal handling into a miniaturized measurement system.
Applications include biosensors, lab-on-a-chip systems, point-of-care diagnostics, and continuous monitoring of physiological or environmental conditions. These settings benefit from compact measurements that can be performed faster while using less sample and reagent material. The same platform can therefore support clinical, research, and environmental measurements, depending on the recognition element and target condition being monitored.
Multiplexing allows a compact platform to make multiple measurements rather than restricting an experiment to a single readout. In bioengineering, this capability is relevant when researchers need to examine several targets or conditions within one measurement format. Combined with small size and portability, multiplexed sensing can support broader data collection in research, clinical, or monitoring applications.