Abnormal Involuntary Movements

Abnormal involuntary movements are unintended, excessive, reduced, or irregular motor actions caused by disrupted control of skeletal muscle activity, providing important clues to nervous-system function. They arise when neural circuits that coordinate movement, including the cerebral cortex, basal ganglia, cerebellum, brainstem, and spinal pathways, generate or fail to suppress motor signals; altered neurotransmission can produce tremor, chorea, dystonia, tics, or myoclonus. Careful observation of these movements helps researchers and clinicians identify affected neural systems, distinguish neurological disorders, monitor disease progression, and evaluate treatment responses. Studying their biological mechanisms also advances knowledge of motor control and brain circuit function.

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Education

JoVE Core - Molecular Biology

Abnormal Proliferation

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2021

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Abnormal Proliferation

0 Views •

2023

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Cardiac Exam III: Abnormal Heart Sounds

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2023

Source: Suneel Dhand, MD, Attending Physician, Internal Medicine, Beth Israel Deaconess Medical Center Having a fundamental understanding of normal heart sounds is the first step toward distinguishing the normal from the abnormal. Murmurs are sounds that represent turbulent and abnormal blood flow across a heart valve. They are caused either by stenosis (valve area too narrow) or regurgitation (backflow of blood across the valve) and are commonly heard as a "swishing" sound during auscultation.

Research

JoVE Journal - Neuroscience

Eye Movement Monitoring of Memory

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Cited by 10 •

2010

Eye movement monitoring (or eye tracking) reveals where in space the eyes linger, when and for how long. Here, we demonstrate how eye tracking can be used to investigate the integrity of memory in multiple participant populations, without requiring verbal, or otherwise explicit, reports.

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

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Cited by 9 •

2012

A 3D culture system for hematopoiesis is described using human cord blood and leukemic bone marrow cells. The method is based on the use of a porous synthetic polyurethane scaffold coated with extracellular matrix proteins. This scaffold is adaptable to accommodate a wide range of cells.

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