Axolotl Vasculature
Axolotl Vasculature - Related Videos
09:58
A Method for Labeling Vasculature in Embryonic Mice
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Cited by 14 •
2011
This article describes a method for labeling embryonic skin and thymus blood vessels.
09:52
Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
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Cited by 25 •
2013
Recently developed imaging techniques using near-infrared fluorescence (NIRF) may help elucidate the role the lymphatic system plays in cancer metastasis, immune response, wound repair, and other lymphatic-associated diseases.
09:03
Trypsin Digest Protocol to Analyze the Retinal Vasculature of a Mouse Model
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Cited by 59 •
2013
Trypsin digest is one of the most commonly used methods to analyze retinal vasculature. This manuscript describes the method in detail, including key alterations to optimize the technique and remove the non-vascular tissue while preserving the overall architecture of the vessels.
09:53
2D and 3D Echocardiography in the Axolotl (Ambystoma Mexicanum)
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Cited by 11 •
2018
Here we present echocardiography protocols for two-dimensional and three-dimensional image acquisition of the beating heart of the axolotl salamander (Ambystoma mexicanum), a model species in heart regeneration. These methods allow for longitudinal evaluation of cardiac function at a high spatiotemporal resolution.
05:08
Egg Windowing: A Method of Opening Fertilized Chicken Egg Shell to Expose Chorioallantoic Membrane Vasculature
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2023
In this video, we describe a technique to open the eggshell of a fertilized chicken egg to expose its chorioallantoic membrane or CAM carrying a network of branching blood vessels. The exposed CAM can be used for in ovo tumor modeling.
FAQs
Endothelial cells form the lining of the blood vessels, placing them at the interface between circulating blood and surrounding tissues. This cellular layer is an important feature when studying how vessels support oxygenation, nutrient delivery, and waste removal. Examining endothelial organization can therefore help connect vessel structure with tissue maintenance and regeneration.
New vessel growth can extend or increase the vascular supply available to tissues as they develop or regenerate. By providing routes for circulating blood to reach these areas, vessel formation may help meet their needs for oxygen and nutrients while supporting waste removal. Vessel remodeling can further adjust the network as tissue requirements change.
Vascular remodeling matters because regenerating tissues do not remain static while they heal or grow. Changes in the vessel network can alter how blood reaches the affected region and may help the circulation adapt to developing tissue. Studying this relationship allows researchers to examine how vascular changes accompany the axolotl’s exceptional regenerative capacity.
Axolotl vasculature provides a context for examining how blood vessels form, adapt, and support tissues. Researchers can consider these processes together rather than treating circulation as separate from development or regeneration. This broader view places vessel biology within comparative developmental biology and helps identify how vascular behavior relates to tissue growth and repair.
Studies can focus on the structure and organization of arteries, veins, capillaries, and their endothelial lining, as well as changes associated with developing or regenerating tissues. Researchers may then relate vessel growth or remodeling to tissue support. The resulting observations help describe how circulation participates in axolotl development and regeneration.
Research on axolotl vasculature may inform investigations of vascular repair, wound healing, and regenerative medicine in other vertebrates. Its value comes from linking vessel formation and remodeling with the salamander’s strong regenerative response. These comparisons can provide biological context for understanding how vascular support may contribute to tissue recovery beyond the axolotl.