Brain Dissection

Brain dissection is the systematic examination of brain structure by separating tissue and identifying major anatomical regions, providing a direct way to study organization in biology. During the procedure, careful incisions and removal of surrounding membranes expose features such as the cerebral hemispheres, cerebellum, brainstem, ventricles, and internal tissue layers while preserving their spatial relationships. In teaching laboratories, brain dissection connects three-dimensional anatomy with nervous system function and supports comparative studies across species. It also provides practical training in specimen handling, observation, and anatomical documentation, helping students and researchers investigate how structural differences relate to behavior, development, disease, and neurological research.

Brain Dissection - Related Videos

Research

JoVE Journal - Biology

The Gateway to the Brain: Dissecting the Primate Eye

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Cited by 7 •

2009

The non-human primate is an important translational species for our understanding of development and aging. The anatomical organization of the primate retina may provide important insights into normal and pathological conditions in humans.

Zebrafish Brain Dissection: A Technique of Fish Neurobiology

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2023

This video describes the technique of microdissection of the brain from an adult zebrafish. This method helps in obtaining whole brain derived neuorospheres that can be studied further.

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices

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Cited by 8 •

2016

Optogenetic approaches are widely used to manipulate neural activity and assess the consequences for brain function. Here, a technique is outlined that upon in vivo expression of the optical activator Channelrhodopsin, allows for ex vivo analysis of synaptic properties of specific long range and local neural connections in fear-related circuits.

Dissection and Mounting of Fruit Fly Larval Brain Explants

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2025

This video demonstrates the dissection and mounting of brain explants from Drosophila larvae. The central nervous system (CNS), attached to eye disks, is extracted from the larvae and then mounted on a glass slide in a physiological saline solution.

Micro-dissection of Rat Brain for RNA or Protein Extraction from Specific Brain Region

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Cited by 171 •

2007

Micro-dissection of rat brain into various regions is extremely important for the study of different neurodegenerative diseases. This video demonstrates micro-dissection of four major brain regions include olfactory bulb, frontal cortex, striatum and hippocampus in fresh rat brain tissue. Useful tips for quick removal of respective regions to avoid RNA and protein degradation of the tissue are given.

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