Capillary Manipulation
Capillary Manipulation - Related Videos
13:27
Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia
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Cited by 50 •
2014
Pneumonia is one of the top ten leading causes of death in the U.S. Osteopathic manipulative techniques (OMT) may be utilized as an adjunctive therapy in the treatment of pneumonia to enhance biomechanical and immune function; and ultimately, to reduce hospital stay, duration of antibiotics, incidence of respiratory failure, and mortality. In this video-article, we will review randomized controlled studies on the use of OMT in pneumonia patients, as well as demonstrate specific hands-on...
08:50
Capillary Electrophoresis (CE)
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2023
Source: Laboratory of Dr. B. Jill Venton - University of Virginia Capillary electrophoresis (CE) is a separation technique that separates molecules in an electric field according to size and charge. CE is performed in a small glass tube called a capillary that is filled with an electrolyte solution. Analytes are separated due to differences in electrophoretic mobility, which varies with charge, solvent viscosity, and size. Traditional electrophoresis in gels is limited in the amount of voltage...
14:53
Capillary Electrophoresis Separation of Monoclonal Antibody Isoforms Using a Neutral Capillary
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Cited by 2 •
2017
Here, we present a comprehensive capillary zone electrophoresis protocol for the assessment of intrinsic physicochemical heterogeneity of monoclonal antibodies as a quality attribute.
03:45
Purifying Capillaries From a Porcine Brain
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2025
This video demonstrates the isolation of capillaries from fresh porcine brains. The process involves removing the meninges, isolating the grey matter from the brain tissue, homogenizing and filtering the grey matter to isolate the capillaries, and finally using enzymatic digestion to purify the capillaries further.
05:17
A Reproducible Computerized Method for Quantitation of Capillary Density using Nailfold Capillaroscopy
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Cited by 17 •
2015
Capillaroscopy is a non-invasive, efficient, relatively inexpensive and easy-to-learn methodology for directly visualizing capillaries in the microcirculation. However, only one publication to date describes the reliability of a complex software program available for quantitating capillaroscopy data. Here, we present a simple, reliable protocol for quantitating capillaries using a standardized algorithm.
FAQs
The micromanipulator converts operator control into precise capillary movement at cellular dimensions. It allows the capillary to be positioned, advanced, or withdrawn in a controlled manner while interacting with a specimen. This mechanical precision helps researchers perform reproducible handling steps and reduces unnecessary contact, which is important when working with delicate cells, embryos, or tissues.
Pressure and suction provide complementary control over fluid movement. Pressure can support delivery or injection through the capillary, whereas suction enables collection or aspiration of material. Connecting the capillary to either system extends manipulation beyond physical positioning, allowing researchers to coordinate movement with controlled microscale transfer during cell, tissue, or embryo procedures.
Minimizing mechanical damage depends on coordinating capillary motion with the specimen and the fluid flow. A narrow capillary provides access at a small scale, while the micromanipulator controls its position and pressure or suction regulates transfer. Together, these elements support precise interaction without relying on uncontrolled movement or excessive handling.
A basic workflow begins by mounting a glass or polymer capillary on a micromanipulator and bringing it into position near the specimen. The operator then uses controlled movement alone or combines it with pressure or suction, depending on whether the task requires positioning, transfer, injection, collection, or aspiration. This sequence links physical placement with fluid control.
Application choice follows the biological task and the scale of the specimen. Capillary manipulation can support cell handling, embryo manipulation, microinjection, tissue sampling, and microscale fluid transfer. These uses make the technique relevant when an experiment requires a small sample or structure to be moved, sampled, or treated with localized control.
In biology, the technique provides a practical bridge between microscale mechanics and experimental investigation. Its reproducible operations at cellular dimensions support work in developmental biology, cell biology, reproductive research, and other experiments requiring precise control. The same manipulation principles can be adapted to cells, embryos, tissues, and small fluid samples.