Chick Cam Model

The Chick Cam Model is a live-imaging approach that uses the developing chicken embryo to visualize vertebrate development, making complex biological processes accessible for study and teaching. A fertilized egg is maintained under controlled incubation conditions, while a camera records the embryo through a viewing window or transparent shell region as cells organize, tissues form, and the circulatory system develops. This model supports direct observation of processes such as gastrulation, organ formation, and vascular growth without relying only on fixed specimens. In biology education and research, Chick Cam provides a practical system for connecting embryonic structure with developmental timing and experimental outcomes.

Chick Cam Model - Related Videos

Research

JoVE Journal - Biology

Chick ex ovo Culture and ex ovo CAM Assay: How it Really Works

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Cited by 110 •

2009

The chick chorioallantoic membrane (CAM) is a unique, naturally immunodeficient supportive culture environment to study angiogenesis and tumorigenesis. This video article demonstrates the different steps in chick ex ovo culture, application of potentially angiogenic substances and successful inoculation of tumor cells and tissues on the surface of the CAM.

The In Ovo Chick Chorioallantoic Membrane (CAM) Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma

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Cited by 62 •

2015

The chick chorioallantoic membrane (CAM) is immunodeficient and highly vascularized, making it a natural in vivo model of tumor growth and angiogenesis. In this protocol, we describe a reliable method of growing three-dimensional, vascularized hepatocellular carcinoma (HCC) tumors using the CAM assay.

The In ovo CAM-assay as a Xenograft Model for Sarcoma

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Cited by 64 •

2013

The in ovo chorioallantoic membrane (CAM) is grafted with fresh sarcoma-derived tumor tissues, their single cell suspensions, and permanent and transient fluorescently labeled established sarcoma cell lines. The model is used to study graft- (viability, Ki67 proliferation index, necrosis, infiltration) and host (fibroblast infiltration, vascular ingrowth) behavior.

Chick Chorioallantoic Membrane or CAM Tumor Model: An In Ovo Method to Simulate Perineural Invasion of Tumor Cells

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2023

In this video, we describe the method to co-culture dorsal root ganglia and cancer cells on chick chorioallantoic membrane or CAM to study perineural invasion.

Education

JoVE Science Education - Basic Biology

An Introduction to the Chick: Gallus gallus domesticus

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2023

The chicken embryo (Gallus gallus domesticus) is an extremely valuable model organism for research in developmental biology, in part because most of their development takes place within an egg that is incubated outside of the mother. As a result, early developmental stages can be accessed, visualized and manipulated by simply creating a small hole in the eggshell. Since billions of chickens are raised worldwide for meat and egg production, scientists can easily and economically acquire large...

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