Colon Cancer Field Defect
Colon Cancer Field Defect - Related Videos
28:15
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Cited by 22 •
2010
Reduced/absent expression of Pms2 and/or ERCC1 in entire crypts is a frequent event within 10 cm on each side of colonic adenocarcinomas, likely the basis of a field defect with high mutability and progression to cancer. Deficiency in Ku86 or CcOI is much less frequent in these field defects.
03:18
Modeling Ovarian Cancer Cell Colonization of Omentum: An Ex Vivo Method to Establish Milky Spot Colonization of Fluorescently Labeled Ovarian Cancer Cells in Murine Omentum Explants
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2023
In this video, we establish an ex vivo omental organ culture overlaid with GFP-expressing ovarian cancer cells to study ovarian cancer colonization within the omental explant. This protocol analyzes immune cell structures within the omentum known as milky spots that promote metastases.
13:04
In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
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Cited by 10 •
2015
We outline a protocol that implements both in vivo and ex vivo approaches to study ovarian cancer colonization of peritoneal adipose tissues, particularly the omentum. Furthermore, we present a protocol to quantitate and analyze immune cell-structures in the omentum known as milky spots, which promote metastases of peritoneal adipose.
08:55
The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
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Cited by 111 •
2016
Mice bearing the Colon-26 (C26) carcinoma represent a classical model of cancer cachexia. Progressive muscle wasting occurs in association with tumor growth, over-expression of muscle-specific ubiquitin ligases, and reductions in muscle cross-sectional area. Fat loss is also observed. Cachexia is studied in a time-dependent manner with increasing severity of wasting.
05:58
Surgical Trunk Oriented Laparoscopic Right Hemicolectomy (ST-LRH) for Right-Sided Colon Cancer
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2025
This protocol describes Surgical Trunk-oriented Laparoscopic Right Hemicolectomy (ST-LRH), a modified laparoscopic right hemicolectomy designed to optimize vascular management and lymph node dissection, simplify surgical procedures, and improve surgical safety and efficiency.
FAQs
Several alteration types may contribute, including genetic changes, epigenetic changes, and genomic instability. Altered interactions between cells and the surrounding tissue may also help extend the field across neighboring regions. Because these processes can affect tissue before a visible tumor forms, studying them may reveal early steps in colorectal cancer development that are not apparent from tumor appearance alone.
Normal appearance does not necessarily indicate the absence of cancer-related abnormalities. Molecular or cellular changes in nearby tissue may signal increased susceptibility to tumor development or indicate that the surrounding region has been affected by processes linked to cancer. This makes such tissue potentially informative for understanding risk, even when no obvious tumor is present.
Tumor-centered analysis focuses on an established, visibly abnormal growth, whereas field-defect analysis also considers tissue surrounding that growth. Examining the nearby region can reveal alterations that extend beyond the tumor itself and may have appeared earlier in development. This broader view helps researchers investigate how colorectal cancer emerges and whether adjacent tissue contains clinically relevant abnormalities.
Researchers may examine colon tissue located near a tumor, especially areas that appear normal but could contain cancer-associated changes. The analysis focuses on molecular and cellular characteristics rather than appearance alone. Comparing these surrounding regions with tumor tissue or unaffected tissue can help determine whether alterations are localized or distributed across neighboring cells.
Field-defect studies can identify molecular or cellular alterations that occur before a visible tumor develops. If particular changes consistently associate with tumor development, they may serve as early biomarkers, meaning measurable signs of increased cancer-related risk. Such markers could improve researchers’ ability to recognize abnormal tissue states and clarify which changes are relevant to colorectal cancer progression.
The findings may contribute to improved surveillance, risk assessment, and approaches for detecting or preventing additional tumors. They can also help explain recurrence by showing whether tissue near a treated or existing tumor contains persistent abnormalities. More broadly, the concept guides research into how cancer-related changes spread through tissue and how those changes might be recognized earlier.