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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
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JoVE Journal Cancer Research
The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

DOI:
10.3791/54893-v

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08:55 min

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November 30, 2016

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, , ,
1Department of Surgery, Simon Cancer Center and IUPUI Center for Cachexia Research, Innovation and Therapy,Indiana University School of Medicine

Chapters

  • 00:05Title
  • 00:58Tumor Cell Implantation and Blood Collection
  • 02:05Tissue and Organ Excision
  • 04:04Muscle Freezing, Mounting, and Sectioning
  • 05:57Results: Representative Muscle Growth Analyses in C26 Tumor-bearing Mice
  • 07:33Conclusion

Summary

Automatic Translation

Automatic Translation

Mice bearing the Colon-26 (C26) carcinoma represent a classical model of cancer cachexia. Progressive muscle wasting occurs in association with tumor growth, over-expression of muscle-specific ubiquitin ligases, and reductions in muscle cross-sectional area. Fat loss is also observed. Cachexia is studied in a time-dependent manner with increasing severity of wasting.

Tags

Keywords: Colon-26 CarcinomaTumor-bearing MouseCancer CachexiaMuscle WastingMuscle WeaknessMuscle CatabolismInflammatory CytokinesTumor ImplantationBlood CollectionMuscle Dissection

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