Dura Mater

Dura mater is the tough, fibrous outermost layer of the meninges, the connective-tissue membranes that surround and protect the brain and spinal cord. In the cranium, its periosteal and meningeal layers attach to the skull, form dural folds such as the falx cerebri, and create venous sinuses that drain blood while helping stabilize the brain. In the vertebral canal, spinal dura forms a protective sleeve around the spinal cord and helps compartmentalize cerebrospinal fluid. Studying dura mater supports understanding of nervous-system anatomy and conditions including traumatic injury, inflammation, meningeal tumors, and disorders affecting intracranial pressure.

Dura Mater - Related Videos

Research

JoVE EoE - Neuroimaging

Investigating the Origins of Sensory Neurons in the Dura Mater Using Fluorescence Microscopy

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2025

Source: Wang, J., et al. Visualizing the Calcitonin Gene-Related Peptide Immunoreactive Innervation of the Rat Cranial Dura Mater with Immunofluorescence and Neural Tracing. J. Vis. Exp. (2021). This video demonstrates a method to trace the origins of sensory neurons in the dura mater using fluorescence microscopy. A retrograde tracer is introduced into the exposed dura mater of an anesthetized rat. The tracer is taken up by sensory neuronal axons and travels retrogradely to their cell bodies...

Visualizing the Calcitonin Gene-Related Peptide Immunoreactive Innervation of the Rat Cranial Dura Mater with Immunofluorescence and Neural Tracing

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Cited by 3 •

2021

Here we present a protocol to visualize spatial correlation of calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers and blood vessels in the cranial dura mater using immunofluorescence and fluorescent histochemistry with CGRP and phalloidin, respectively. In addition, the origin of these nerve fibers was retrograde traced with a fluorescent neural tracer.

Subdural Implantation of a Soft Electrocorticography Array for Cortical Electrophysiology Recording in Minipigs

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2025

This video demonstrates the implantation of a soft electrocorticography array and the long-term cortical recordings in a minipig. It outlines the steps involved in surgically implanting the array over the minipig's auditory cortex and recording both baseline and sound stimulus-evoked neuronal action potentials.

Generating a Mouse Model of Traumatic Brain Injury Using an Impactor Device

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2025

This video demonstrates the procedure for inducing traumatic brain injury (TBI) in a mouse model. An anesthetized mouse with an exposed skull is taken to create an opening in the skull, and then a controlled cortical injury is induced using an impact device. The injury damages the brain tissue, causing impaired cognitive function and motor coordination.

Intracerebroventricular Injection in Mouse: An Ommaya Mediated Direct Drug Administration Method to Deliver Drugs to Cerebral Ventricles of Mouse Brain

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2023

This video demonstrates ommaya mediated intracerebroventricular injection in a mouse model. The method enables localized delivery of potential drug candidates and evades the blood-brain barrier.

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