Genetic Fitness

Genetic fitness is an evolutionary measure of how effectively an organism’s heritable traits contribute to survival and reproduction relative to other individuals in a population. Rather than describing physical condition alone, it reflects reproductive success: traits that increase the production of viable, fertile offspring can become more common when natural selection shifts allele frequencies across generations. In biology, comparing genetic fitness helps explain adaptation, competition, population change, and the persistence or loss of genetic variants. These comparisons also support studies of evolutionary responses to environmental pressures and disease.

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Research

JoVE Journal - Biology
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A Quantitative Fitness Analysis Workflow

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Cited by 25 •

2012

Quantitative Fitness Analysis (QFA) is a complementary series of experimental and computational methods for estimating microbial culture fitnesses. QFA estimates the effect of genetic mutations, drugs or other applied treatments on microbe growth. Experiments scaling from focussed analysis of single cultures to thousands of parallel cultures can be designed.

Education

JoVE Core - Biology

Induced-fit Model

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2019

Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon. Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical characteristics of...

Goodness-of-Fit Test

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2025

The goodness-of-fit test is a type of hypothesis test which determines whether the data "fits" a particular distribution. For example, one may suspect that some anonymous data may fit a binomial distribution. A chi-square test (meaning the distribution for the hypothesis test is chi-square) can be used to determine if there is a fit. The null and alternative hypotheses may be written in sentences or stated as equations or inequalities. The test statistic for a goodness-of-fit test is given as...

Inclusive Fitness

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2025

Most altruistic behavior—in which one animal helps another at a cost to themselves—occurs between relatives. Scientists think these altruistic behaviors evolved because they increase the inclusive fitness of the animal providing help. Inclusive fitness is an individual’s ability to pass down their genes—both through their offspring and the offspring of close relatives with shared genes. If an animal helps a close relative improve their reproductive success, this increases the animal’s...

An Overview of Genetic Analysis

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2023

An organism’s physical traits, or phenotype, are a product of its genotype, which is the combination of alleles (gene variants) inherited from its parents. To varying degrees, genes interact with each other and environmental factors to generate traits. The distribution of alleles and traits within a population is influenced by a number of factors, including natural selection, migration, and random genetic drift.In this video, JoVE introduces some of the foundational discoveries in genetics,...

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