Hair Papilla
Hair Papilla - Related Videos
10:50
Denver Papillae Protocol for Objective Analysis of Fungiform Papillae
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Cited by 47 •
2015
Here we present a protocol to measure fungiform papilla density from digital photographs. This method builds prioritization and objective characteristic metrics into the original descriptive work on fungiform papillae by Miller & Reedy (1990).
09:39
Technique to Collect Fungiform (Taste) Papillae from Human Tongue
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Cited by 30 •
2010
Knowledge of molecular mechanisms underlying gustatory transduction has recently enjoyed significant advances, largely due to using animal models. However, the wide diversity in taste sensitivity and specificity among mammals warrants studies in human tissue. We describe a biopsy technique to collect living taste cells from the papillae on human tongue.
08:46
Isolation and Culture of Human Fungiform Taste Papillae Cells
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Cited by 20 •
2012
We aimed to develop a reproducible protocol for isolating and maintaining long-term cultures of human fungiform taste papillae cells. Cells from human fungiform papillae obtained by biopsy were successfully maintained in culture for more than eight passages (12 months) without loss of viability.
01:22
Hair Cells
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2019
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here. Hair cells are named after...
03:38
Isolation of Circumvallate Papillae (CVP) Epithelium from Mouse Model: An Enzymatic Procedure to Separate CVP Epithelium from Mouse Tongue
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2025
In this video, we describe the isolation of circumvallate papillae (CVP) epithelium from a murine tongue.
FAQs
Molecular signals and direct cell communication connect the hair papilla with surrounding matrix keratinocytes. These interactions promote keratinocyte proliferation and differentiation, enabling the cells to contribute to hair-shaft production during the growth phase. Examining this communication helps explain how dermal and epithelial components coordinate follicle activity rather than functioning as independent cell populations.
The level of hair papilla activity influences how strongly surrounding matrix keratinocytes proliferate and differentiate. Greater or reduced signaling can therefore alter the size of the follicle and the resulting thickness of the hair shaft. This relationship makes papilla activity an important biological variable when investigating differences in hair production and follicle behavior.
Changes in papilla activity are associated with movement between the follicle’s growth, regression, and resting phases. During growth, papilla-mediated interactions support matrix-cell activity and hair-shaft production, while altered activity accompanies later cycle transitions. Studying these changes helps researchers connect cellular signaling with the timing and pattern of hair-cycle behavior.
Research on the hair papilla can clarify how follicle development is regulated through interactions between dermal mesenchymal cells and matrix keratinocytes. It can also reveal how signaling influences follicle size, hair thickness, and cycling. These findings provide biological context for understanding normal follicle formation and how developmental regulation may change in disease or repair.
Because papilla activity influences hair-shaft production and follicle cycling, researchers can examine whether altered activity corresponds with reduced growth, changes in thickness, or abnormal transitions into regression or rest. This provides a framework for investigating hair loss disorders at the level of follicle regulation, rather than considering hair loss only as a visible outcome.
Hair papilla biology connects follicle regulation with research on wound healing and regenerative strategies. Its signaling relationships with matrix keratinocytes offer a model for studying how cellular communication supports organized tissue activity. Researchers also use this knowledge when exploring approaches intended to restore or enhance hair growth, while assessing how papilla-related regulation affects follicle outcomes.