Heat Stroke
Heat Stroke - Related Videos
04:32
Exertional Heat Stroke Mouse Model: A Protocol to Study Mechanisms Underlying Exertional Heat Stroke
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2025
In this video we describe a step-by-step protocol to study exertional heat stroke (EHS) in a mouse model.
08:22
A Preclinical Model of Exertional Heat Stroke in Mice
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Cited by 19 •
2021
The protocol describes the development of a standardized, repeatable, preclinical model of exertional heat stroke (EHS) in mice free from adverse external stimuli such as electric shock. The model provides a platform for mechanistic, preventative, and therapeutic studies.
08:14
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
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Cited by 104 •
2014
Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.
02:46
Quantifying Heat
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2025
Thermal Energy Microscopically, thermal energy is the kinetic energy associated with the random motion of atoms and molecules. Temperature is a quantitative measure of “hot” or “cold”, which depends on the amount of thermal energy. When the atoms and molecules in an object are moving or vibrating quickly, they have a higher average kinetic energy (KE) (or higher thermal energy), and the object is perceived as “hot”, or it is described as being at a higher temperature. When the atoms and...
01:12
Heat Flow and Specific Heat
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2023
Heat is a type of energy transfer that is caused by a temperature difference, and it can change the temperature of an object. Since heat is a form of energy, its SI unit is the joule (J). Another common unit of energy often used for heat is the calorie (cal), which is defined as the energy needed to change the temperature of 1 g of water by 1 °C, specifically between 14.5 °C and 15.5 °C, since the energy needed shows a slight temperature dependence. Another commonly used unit is the kilocalorie...
FAQs
Thermoregulation depends on coordinated activity across the nervous, cardiovascular, and endocrine systems. These systems organize responses to rising body heat and support processes such as skin blood flow and sweating. When their combined responses cannot match heat gain, physiological strain spreads beyond temperature control, helping explain why Heat Stroke can involve the brain, kidneys, muscles, and other organs.
Each cooling pathway addresses a different part of heat balance. Sweating places water on the skin, skin blood flow helps move heat toward the body surface, and evaporation removes heat from that moisture. Hot environmental conditions or intense activity can increase heat gain faster than these processes can dissipate it, promoting rising core temperature and fluid disruption.
Fluid balance becomes threatened when heat stress places sustained demands on sweating and other cooling responses. Water loss and impaired heat dissipation can occur together, increasing physiological strain. This connection matters because fluid disruption is not an isolated effect; it can accompany cellular dysfunction and contribute to complications involving the brain, kidneys, muscles, and other organs.
Heat Stroke can produce systemic injury because excessive core temperature disrupts cellular function rather than affecting only the skin or muscles. The overview identifies possible complications in the brain, kidneys, muscles, and other organs. This broad impact makes rapid recognition important, since maintaining stable temperature and fluid conditions is essential for limiting progression.
Rapid recognition should focus on the combination of dangerously elevated core temperature and neurological dysfunction, especially during heat exposure or strenuous exercise. This pattern connects the observed condition to a serious failure of thermal regulation and signals the need for immediate cooling. Recognizing both temperature and nervous-system effects helps identify physiological danger before complications progress.
Immediate cooling addresses the primary physiological problem by reducing the heat burden when natural dissipation cannot keep pace. The goal is to interrupt progression from excessive heat gain to worsening cellular and fluid disruption. Prompt action matters because continued elevation of core temperature can increase the risk of complications involving the brain, kidneys, muscles, and other organs.