Human-assisted Gene Flow

Human-assisted gene flow is the deliberate movement of organisms or their reproductive material between populations to introduce genetic variation and connect otherwise isolated gene pools. It works through actions such as translocating individuals, transferring seeds or pollen, or managing breeding between populations, allowing alleles to enter and spread through reproduction. In biology and conservation, these interventions can reduce inbreeding, restore genetic diversity, and support populations affected by habitat fragmentation or environmental change. Careful assessment is needed to match donor and recipient populations, limit disease transmission, and avoid disrupting local adaptations, making human-assisted gene flow an important tool for population management and evolutionary research.

Human-assisted Gene Flow - Related Videos

Education

JoVE Core - Biology

Gene Flow

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2026

Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals. This phenomenon plays a significant evolutionary role in all organisms, and depending on the rates of gene flow, the mechanism either induces genetic diversity or generates genetic homogeneity among populations. When the rate of gene flow is low, the introduction of new alleles into a population generates genetic diversity. On the other hand, a high rate of...

Research

JoVE EoE - Gene Transfer Techniques

Laser-Assisted Lentiviral Gene Delivery: A Technique to Permeabilize Mouse Fertilized Eggs to Facilitate Lentiviral Gene Delivery

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2025

In this video, we demonstrate the laser-assisted permeation of the protective layer of zona pellucida in mouse fertilized eggs for facilitating lentiviral gene delivery. Lentivirus enables the generation of transgenic animals with a gene of interest stably integrated into their genome.

Analysis of Gene Function and Visualization of Cilia-Generated Fluid Flow in Kupffer's Vesicle

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Cited by 19 •

2013

Cilia-generated fluid flow in Kupffer’s Vesicle (KV) controls left-right patterning of the zebrafish embryo. Here, we describe a technique to modulate gene function specifically in KV cells. In addition, we show how to deliver fluorescent beads into KV to visualize fluid flow.

PiggyBac Transposon-Mediated Gene Editing in Human iPSCs: A Procedure to Integrate Gene of Interest in Human iPSCs Using PiggyBac Transposon System

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2025

This video demonstrates the procedure to generate motor neurons by transfection of human iPSCs with PiggyBac transposon system by the ectopic expression of lineage-specific transcription factors.

Research

JoVE Journal - Immunology and Infection
Free Sample

Human Neutrophil Flow Chamber Adhesion Assay

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Cited by 12 •

2014

A method of quantitating neutrophil adhesion is reported. This method creates a dynamic flow environment similar to that encountered in a blood vessel. It allows the investigation of neutrophil adhesion to either purified adhesion molecules (ligand) or endothelial cell substrate (HUVEC) in a context similar to the in vivo environment with sheer stress.

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