Microwave Assisted Synthesis

Microwave-assisted synthesis is a chemical technique that uses microwave energy to accelerate reactions, often reducing heating time and energy use compared with conventional methods. Microwaves heat reaction mixtures through dipole rotation and ionic conduction, causing polar molecules and charged species to convert electromagnetic energy into heat throughout the sample; temperature, solvent choice, and reaction conditions influence the outcome. In biology, this approach supports the preparation of bioactive compounds, molecular probes, and materials for studying biological systems. Faster synthesis and potentially improved reproducibility can streamline drug discovery, biochemical research, and the development of biomaterials.

Microwave Assisted Synthesis - Related Videos

Research

JoVE Journal - Biology

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)

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Cited by 15 •

2011

A facile, one-pot synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) was developed based on a non-aqueous, three-step radiochemical process. Using microwave heating, the entire procedure can be completed in less than 30 min, or 60 min with further purification by preparative HPLC. The decay-corrected radiochemical yields (RCYs) were 35-5% (n > 30).

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes

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Cited by 2 •

2013

Microwave-assisted intramolecular dehydrogenative Diels-Alder (DA) reactions provide concise access to functionalized cyclopenta[b]naphthalene building blocks. The utility of this methodology is demonstrated by one-step conversion of the dehydrogenative DA cycloadducts into novel solvatochromic fluorescent dyes via Buchwald-Hartwig palladium-catalyzed cross-coupling reactions.

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

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Cited by 11 •

2013

Silica nanoparticles were prepared using acid-catalysis of a siloxane precursor and microwave-assisted synthetic techniques resulting in the controlled growth of nanomaterials ranging from 30-250 nm in diameter. The growth dynamics can be controlled by varying the initial silicic acid concentration, time of the reaction, and temperature of reaction.

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis

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2024

A simple, inexpensive, and novel apparatus for performing solid phase peptide syntheses in a commercial microwave reactor is presented.

Research

JoVE Journal - Chemistry
Free Sample

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

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Cited by 32 •

2013

This video will illustrate a rapid, efficient method to methacrylate poly(ethylene glycol), enabling chain polymerizations and hydrogel synthesis. It will demonstrate how to similarly introduce methacrylamide functionalities into peptides, detail common analytical methods to assess functionalization efficiency, provide suggestions for troubleshooting and advanced modifications, and demonstrate typical hydrogel characterization techniques.

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