Neurons Glial Cells

Neurons and glial cells are the two major cellular components of nervous tissue, working together to receive, process, and transmit information while maintaining neural function. Neurons generate electrical impulses through regulated ion movement across their membranes and communicate at synapses by releasing neurotransmitters, whereas glial cells support neurons by regulating their environment, providing metabolic assistance, and, in some cases, forming myelin. Studying these cells helps explain sensation, movement, learning, and neural development, while revealing how cellular dysfunction contributes to neurological disease. Cellular and molecular methods that examine neuronal signaling, glial interactions, and tissue organization support research in neurobiology, disease modeling, and therapeutic development.

Neurons Glial Cells - Related Videos

Research

JoVE EoE - Neuronal Culture Techniques

Generating Neurons and Glial Cells from Human Induced Pluripotent Stem Cell-Derived Embryoid Bodies

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2025

This video demonstrates the process of differentiating embryoid bodies (EBs) into neuroepithelial aggregates and their subsequent division into neuronal and glial cells. This method allows the efficient generation of neuronal and glial cells in vitro, which serve as test systems for toxicity testing as well as assessment of different pathways involved in neurotoxicity.

Obtaining a Mixed Glial Cell Culture from a Neonatal Mouse Brain

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2025

The video demonstrated the method of isolating and culturing cells from a neonatal mouse brain. It involved enzymatic and mechanical dissociation of the brain, followed by culturing in growth media lacking neuronal growth factor to obtain a mixed glial population.

Education

JoVE Core - Biology

Glial Cells

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2025

Overview Glial cells are one of the two main types of cells in the nervous system. Glia cells comprise astrocytes, oligodendrocytes, microglia, and ependymal cells in the central nervous system, and satellite and Schwann cells in the peripheral nervous system. These cells do not communicate via electrical signals like neurons do, but they contribute to virtually every other aspect of nervous system function. In humans, the number of glial cells is roughly equal to the number of neurons in the...

Study Glial Cell Heterogeneity Influence on Axon Growth Using a New Coculture Method

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Cited by 5 •

2010

In this protocol, we described a new method to study the influence of glial cell heterogeneity on axon growth with an in vitro co-culture system. Rat cortical glial cells were cultured to confluence and cocultured with highly purified rat dorsal root ganglia neurons. Different glial cell influence on neurons adhesion and axon growth was compared directly in the same culture. This method provides a new way to directly study the glial cell heterogeneity influence on neuron adhesion and axon...

Isolating Enteric Glial Cells From the Submucosa and Lamina Propria of a Mouse

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2025

This video demonstrates a method for isolating enteric glial cells from the submucosa and lamina propria of the mouse intestine. It outlines the steps involved in extracting submucosa and lamina propria tissue, isolating the enteric glial cells from them, and culturing the cells on a coated well-plate to establish an enteric glial cell culture.

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