Quartz Vete Exposure
Quartz Vete Exposure - Related Videos
02:58
Rodent Brain Microinjection Using a Quartz Microneedle
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2025
Source: Paolone, G., et al. Personalized Needles for Microinjections in the Rodent Brain. J. Vis. Exp. (2018).This video demonstrates a rodent brain microneedle injection using a quartz microneedle with holes. The microneedle is attached to a syringe and micropump to control the delivery rate. The needle with the injection solution is inserted into the brain with the delivery speed set at low. Once positioned, the delivery speed is increased. The needle is withdrawn after a brief pause.
07:37
Preparation of Macroporous Epitaxial Quartz Films on Silicon by Chemical Solution Deposition
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Cited by 7 •
2015
A protocol is presented for the preparation of piezoelectric macroporous epitaxial films of quartz on silicon by solution chemistry using dip-coating and thermal treatments in air.
06:00
Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection
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2025
We present a laparoscopic technique for anatomic S7+S8d resection with right hepatic vein transection, preserving the inferior right hepatic vein and segment S6. Relying on meticulous anatomical landmarks without intraoperative ultrasound, this approach offers a precise and parenchyma-sparing option for dorsally located right-liver tumors, particularly in settings with limited advanced navigation resources.
09:10
Human Saphenous Vein Endothelial Cell Isolation and Exposure to Controlled Levels of Shear Stress and Stretch
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Cited by 1 •
2023
We describe a protocol to isolate and culture human saphenous vein endothelial cells (hSVECs). We also provide detailed methods to produce shear stress and stretch to study mechanical stress in hSVECs.
07:11
Sampling Blood from the Lateral Tail Vein of the Rat
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Cited by 82 •
2015
Blood samples are useful for assessing biomarkers of physiological states or disease in vivo. Here we describe the methodology to sample blood from the lateral tail vein in the rat. This method provides rapid samples with minimal pain and invasiveness.
FAQs
After respirable particles reach the lungs, immune cells attempt to remove them but can sustain an inflammatory response when particle clearance does not resolve the exposure. This persistent activity contributes to cellular injury and tissue signaling. Studying these responses helps investigators connect particle contact with respiratory effects and identify biological changes associated with long-term pulmonary disease.
Oxidative stress is one of the biological responses examined after quartz particles contact lung tissue. Alongside persistent inflammation, it helps explain how exposure can injure cells and maintain signaling associated with disease progression. Measuring these responses allows researchers to compare toxic effects across exposure conditions and investigate biomarkers that may indicate silica-related biological damage.
Persistent inflammatory and injury-related signaling can promote collagen deposition in lung tissue. As collagen accumulates, normal tissue structure may become progressively altered, producing fibrosis. Quartz exposure models are useful for examining this sequence because they connect particle contact with immune activation, cellular stress, collagen-related changes, and the longer-term pulmonary outcomes relevant to silica-associated disorders.
Quartz exposure studies examine dose-dependent toxicity, meaning that biological effects are evaluated in relation to the amount of particle exposure. Outcomes may include cellular injury, immune responses, oxidative stress, or signals associated with collagen deposition. Comparing doses helps investigators characterize toxicity patterns and supports interpretation of risk in environmental health and occupational research.
A model can be used to examine several linked outcomes rather than a single endpoint. Investigators may assess cellular injury, immune responses, oxidative stress, persistent inflammation, dose-dependent toxicity, and signaling related to collagen deposition or fibrosis. Together, these measurements show how exposure affects respiratory biology and help identify changes that may serve as biomarkers.
These studies provide biological evidence for occupational risk assessment by showing how respirable particles may produce injury and long-term pulmonary changes. Their findings can support safer workplace practices, guide evaluation of exposure-related hazards, and inform searches for biomarkers or interventions for silica-related disorders. The same research also contributes to broader environmental health investigations of respiratory toxicity.