Reid Index
Reid Index - Related Videos
10:12
A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
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Cited by 16 •
2013
Measuring biomarkers in complex biological samples is increasingly guiding clinical decision-making. We describe a highly sensitive method to simultaneously measure cardiac myosin binding protein-C, creatine kinase MB, and cardiac troponin I in serum samples from subjects with myocardial infarction and healthy control subjects.
09:10
Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
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2022
A detailed protocol is presented for preparing the bacteriostatic diamide masarimycin, a small molecule probe that inhibits the growth of Bacillus subtilis and Streptococcus pneumoniae by targeting cell wall degradation. Its application as a chemical probe is demonstrated in synergy/antagonism assays and morphological studies with B. subtilis and S. pneumoniae.
07:28
Measurement of Bioelectric Current with a Vibrating Probe
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Cited by 15 •
2011
The manufacture, calibration and use of non-invasive vibrating probes to measure bioelectric current in various biological systems is described.
07:15
A Novel Method for In Situ Electromechanical Characterization of Nanoscale Specimens
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Cited by 2 •
2017
Isolating electrical and thermal effects on electrically assisted deformation (EAD) is very difficult using macroscopic samples. Metallic sample micro- and nanostructures together with a custom test procedure have been developed to evaluate the impact of applied current on the formation without joule heating and evolution of dislocations on these samples.
08:02
Generation of Local CA1 γ Oscillations by Tetanic Stimulation
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Cited by 2 •
2015
Oscillations are fundamental network properties and are modulated by disease and drugs. Studying brain-slice oscillations allows characterization of isolated networks under controlled conditions. Protocols are provided for the preparation of acute brain slices for evoking CA1 γ oscillations.
FAQs
The denominator is essential because it expresses gland thickness relative to the bronchial wall segment between the epithelium and cartilage. This normalization helps account for differences in overall wall size, allowing glandular enlargement to be represented as a proportion rather than as an isolated thickness measurement. It therefore supports more consistent microscopic assessment.
An increased value reflects a greater share of the measured bronchial wall occupied by submucosal glands. In the context of chronic bronchitis, that structural change indicates increased glandular development and mucus-producing capacity. The finding is relevant because greater mucus production can contribute to airway obstruction and help explain persistent cough.
Gland hypertrophy changes the structure of the bronchial wall while also increasing the tissue's mucus-producing capacity. That connection links a histological observation to functional consequences in the airway: increased mucus production can contribute to obstruction, while the same remodeling pattern is associated with the persistent cough characteristic of chronic bronchitis.
Microscopic evaluation first identifies the submucosal gland layer and the bronchial wall interval extending from the epithelium to the cartilage. The thickness of the gland layer is then divided by the thickness of that wall interval. This calculation converts the observed tissue dimensions into a standardized estimate of glandular enlargement.
Researchers use the measure when examining structural airway changes in chronic bronchitis or relating tissue architecture to respiratory disease. Because it focuses on gland development within the bronchial wall, the result provides a tissue-level counterpart to changes in mucus production, airway obstruction, and persistent cough. Its main value is connecting microscopic structure with pathology.
In biology, the index provides a quantitative way to describe how bronchial gland structure changes rather than relying only on a visual impression of tissue sections. By expressing gland thickness relative to the surrounding wall, it helps organize microscopic observations of airway remodeling and relate those observations to chronic respiratory disease processes.