Remodeling Phase
Remodeling Phase - Related Videos
02:54
Nucleosome Remodeling
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2020
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure. Nucleosome remodeling complex Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
10:14
Biochemical Assays for Analyzing Activities of ATP-dependent Chromatin Remodeling Enzymes
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Cited by 4 •
2014
Here we describe biochemical assays that can be used to characterize ATP-dependent chromatin remodeling enzymes for their abilities to 1) catalyze ATP-dependent nucleosome sliding, 2) engage with nucleosome substrates, and 3) hydrolyze ATP in a nucleosome- or DNA-dependent manner.
07:31
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
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Cited by 26 •
2016
A rat model of abdominal aortic constriction that induces cardiac hypertrophy and remodeling is described. An efficient, highly-reproducible, and minimally-invasive method is used to provide a simple yet useful platform for research in myocardial hypertrophy and dysfunction.
02:39
Phase Diagrams
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2020
A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
01:40
Bone Remodeling
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2025
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling. Hormonal Control of Bone Remodeling Parathyroid hormone (PTH) maintains homeostatic control of blood calcium levels by regulating bone resorption. PTH is...
FAQs
The Remodeling Phase depends on coordinated collagen turnover rather than uninterrupted matrix accumulation. Enzymes remove selected components of the provisional extracellular matrix while fibroblasts support deposition of new collagen. This controlled replacement changes the composition and organization of repaired tissue, allowing the matrix to become more structured instead of remaining in its early, provisional state.
Collagen alignment and cross-linking help determine how effectively repaired tissue withstands mechanical demands. As newly deposited collagen becomes organized and interconnected, the matrix gains greater stability and strength. These changes also influence the appearance of the repair, so remodeling affects both functional recovery and the visible evolution of scar tissue.
Fibroblasts remain important because their activity contributes to ongoing collagen deposition while enzymes regulate removal of selected matrix components. This continuing turnover means that tissue properties do not become fixed immediately after closure. Over months, changing fibroblast activity and collagen organization can alter the strength and appearance of the repaired area.
Researchers can consider how the extracellular matrix is reorganized, how effectively collagen becomes aligned and cross-linked, and whether tissue stability improves over time. Mechanical strength and appearance provide additional outcomes for evaluating repair. Together, these features help distinguish progressive functional recovery from remodeling patterns associated with excessive or abnormal scarring.
Abnormal scarring can be investigated by examining whether matrix breakdown, collagen deposition, alignment, or cross-linking proceeds in an appropriate pattern. Because remodeling influences both tissue strength and appearance, deviations may reveal why a repair becomes excessively scarred or fails to regain normal function. This makes the phase relevant to studies of healing quality and scar development.
Understanding collagen turnover and matrix reorganization can guide treatments intended to support functional tissue recovery. A useful approach would need to account for both removal of selected matrix components and formation of stronger, better-organized collagen. Research can therefore use remodeling biology to evaluate whether an intervention improves stability while limiting undesirable changes in scar tissue.