Running Suture

A running suture is a wound-closure technique in which one continuous strand of suture material passes through successive tissue bites to approximate wound edges. The suture is anchored at the beginning and secured at the end, while consistent spacing and tension distribute mechanical support along the incision; excessive tension can impair tissue perfusion and healing. Commonly used in surgical procedures and experimental biology, running sutures enable rapid closure of long, linear wounds and may produce an even seal when placed accurately. Understanding needle passage, tissue alignment, knot security, and suture tension helps practitioners reduce gaping, minimize tissue trauma, and support effective repair.

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Research

JoVE EoE - Large Animal Models

Q Suture Technique: A Suturing Technique to Reduce Gap Formation and Increase Tensile Strength in Tendon Repair

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2025

In this video, we demonstrate suturing techniques — core suture and Q suture — to repair the foot flexor tendon in an ex vivo porcine model. Q sutures enhance the strength of the core suture in tendon repair and decrease gapping at the tendon repair site.

Education

JoVE Core - Statistics

Wald-Wolfowitz Runs Test II

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2025

The Wald-Wolfowitz runs test, commonly referred to as the runs test, is a nonparametric test used to assess the randomness of ordered data. The test evaluates the number of runs, which are consecutive sequences of similar elements within the data. If the number of runs is significantly higher or lower than expected, the data is considered non-random, indicating a detectable pattern or structure. For binary data, runs are identified using symbols such as + and −, or equivalently, 1s and 0s. In...

Wald-Wolfowitz Runs Test I

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2025

The Wald-Wolfowitz test, also known as the runs test, is a nonparametric statistical test used to assess the randomness of a sequence of two different types of elements (e.g., positive/negative values, successes/failures). It examines whether the order of the elements in a sequence is random or if there is a pattern or trend present. This nonparametric test applies to any ordered data despite the population and sample data distribution, even if a higher sample size is available. The test works...

Sutures of the Skull

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2025

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures. Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

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2025

This protocol describes an effective voluntary wheel-running model that can be implemented in various research contexts. Unlike other voluntary running models, this method avoids isolation housing while tracking running metrics in individual mice.

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