Skip Lesions
Skip Lesions - Related Videos
10:30
Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy
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Cited by 25 •
2016
Exon skipping is currently a most promising therapeutic option for Duchenne muscular dystrophy (DMD). To expand the applicability for DMD patients and to optimize the stability/function of the resulting truncated dystrophin proteins, a multi-exon skipping approach using cocktail antisense oligonucleotides was developed and we demonstrated systemic dystrophin rescue in a dog model.
09:22
Sectioning Mammary Gland Whole Mounts for Lesion Identification
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Cited by 13 •
2017
We developed a method to successfully remove, process, section, and stain, for histopathological evaluation, mammary tissue that had originally been fixed on slides as whole mounts. This method may promote the collection and evaluation of mammary gland whole mounts in reproductive and developmental test guideline studies.
08:16
Comparative Lesions Analysis Through a Targeted Sequencing Approach
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2019
This article describes a method to identify clonal and subclonal alterations among different specimens from a given patient. Although the experiments described here focus on a specific tumor type, the approach is broadly applicable to other solid tumors.
06:20
Exon Skipping in Directly Reprogrammed Myotubes Obtained from Human Urine-Derived Cells
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Cited by 6 •
2020
In this article, we describe a detailed protocol for efficient modelling of Duchenne muscular dystrophy muscle using MYOD1-converted urine-derived cells to evaluate the restoration of dystrophin mRNA and protein levels after exon skipping.
09:26
Preparation and Using Phantom Lesions to Practice Fine Needle Aspiration Biopsies
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Cited by 6 •
2009
Practicing of fine needle aspiration biopsies (FNAB) by trainees is relatively challenging, due to the lack of an easily available, appropriate lesion. Preparation of an AV phantom lesion for practicing the FNAB procedure and mastering proficiency is relatively easy.
FAQs
Skip lesions are informative because they reveal a nonuniform inflammatory process. Affected segments may show ulceration or thickening while nearby mucosa remains relatively preserved, creating a spatial contrast that is biologically meaningful. This pattern helps investigators examine how localized intestinal inflammation alters tissue structure and function without assuming that the entire tract is affected equally.
These tissue features provide complementary evidence about the distribution and structural effects of inflammation. Ulceration indicates surface damage, wall thickening reflects altered tissue structure, and relatively preserved mucosa identifies intervening regions with less apparent involvement. Considering them together helps distinguish a patchy inflammatory pattern from one affecting the gastrointestinal tract more continuously.
Their distribution provides an important contrast between two inflammatory disease patterns. Scattered affected segments with intervening relatively normal regions support the pattern most strongly associated with Crohn’s disease, whereas more continuous inflammation is associated with ulcerative colitis. The distinction helps researchers and clinicians interpret tissue abnormalities in relation to disease classification.
Patchy inflammation allows researchers to study differences between affected and relatively preserved intestinal regions within the same gastrointestinal tract. Those contrasts can clarify how localized disease alters tissue structure and function. In this context, Skip lesions are not only a diagnostic observation but also a model for examining the spatial organization of inflammatory effects.
Recognition depends on evaluating the distribution of abnormal tissue across the gastrointestinal tract. Endoscopy can identify visible changes, imaging can show abnormalities along the tract, and histopathological examination can assess tissue samples. Using these approaches to look for separated abnormal regions supports interpretation of the characteristic patchy pattern rather than relying on one location alone.
Histopathological examination adds tissue-level assessment to the broader distribution seen with endoscopy or imaging. It can help evaluate abnormal areas alongside regions that appear relatively preserved, linking the observed pattern to changes in tissue structure. This complementary perspective is valuable when studying how localized inflammation is expressed within the gastrointestinal tract.
The distribution indicates that inflammatory involvement is localized rather than uniform throughout the gastrointestinal tract. Researchers can use this pattern to relate separated areas of ulceration and wall thickening to regional changes in tissue structure and function. It therefore contributes both to recognizing Crohn’s disease and to investigating the biology of patchy intestinal inflammation.