Trans Fats
Trans Fats - Related Videos
09:25
Transplantation Into the Mouse Ovarian Fat Pad
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Cited by 7 •
2016
We describe an ovarian fad pad transplantation assay suitable for studies of normal and transformed epithelia of the female reproductive tract. The mouse fat pad allows transplantation of large tissue fragments, is easily accessible for surgery and imaging, and provides the most favorable native environment for tissues of Müllerian origin.
04:16
Stromal Vascular Fraction-Enriched Fat Grafting for the Management of Symptomatic Neuromas
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2025
Source: Zimmermann, S., et.al. Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata. J. Vis. Exp. (2017)This video demonstrates the surgical procedure for neurolysis and stromal vascular fraction (SVF)-enriched fat grafting in the management of symptomatic neuroma. Neurolysis removes adhesion tissue to restore nerve gliding, while SVF-enriched fat grafting is applied around the nerve to create a protective barrier, support nerve healing, and enhance...
06:11
An Efficient Method to Obtain Dedifferentiated Fat Cells
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Cited by 4 •
2016
We have modified the conditions for DFAT cell generation and provide herein information regarding the use of an improved growth medium for the production of these cells.
06:41
Decellularizing Mammary Fat Pads: Deriving Extracellular Matrix Hydrogels from Mammary Fat Pads
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2023
This video describes a technique of deriving extracellular matrix hydrogels by decellularizing murine mammary fat pads following ex vivo irradiation for in vitro studies. This hydrogel helps to mimic the in vivo breast tissue environment post-radiation treatment to study tumor cell behavior.
03:53
Ovarian Fat Pad Transplantation Assay: An In Vivo Technique to Introduce Cells into Ovarian Fat Pad in Mouse Models
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2023
In this video, we demonstrate an assay for transplantation of experimental cells and tissue fragments into the mouse ovarian fat pad. This method can be used to monitor cell regeneration and tumor transformation via non-invasive techniques.
FAQs
The trans configuration gives the molecule a straighter shape than the cis arrangement typical of many unsaturated fats. That structural difference can change how neighboring lipid molecules pack together. As a result, the geometry of the double bond helps determine how trans fats behave in biological membranes and how their effects differ from those of other unsaturated fatty acids.
After entering cell membranes, trans fats can influence lipid packing, meaning the way membrane molecules arrange and interact. Changes in packing may modify overall membrane properties and the behavior of the lipid environment surrounding cellular components. These effects provide a biological mechanism linking dietary trans fats with changes in cellular lipid organization and function.
Trans fats can affect lipid metabolism, the biological processing and handling of fats in the body. This influence is relevant because altered lipid metabolism is associated with unfavorable blood-lipid profiles. Studying the connection helps researchers relate molecular changes in lipid handling to broader biological outcomes, including the cardiovascular disease risk associated with trans-fat exposure.
Natural trans fats arise in some ruminant products, whereas industrial trans fats can form when vegetable oils undergo partial hydrogenation. Partial hydrogenation rearranges double-bond geometry and produces straighter molecules. Comparing these sources helps biology and nutrition research examine how origin and molecular structure relate to membrane effects, lipid metabolism, and health outcomes.
A biological investigation can follow trans fats from their presence in cell membranes to changes in lipid packing, membrane properties, and lipid metabolism. Researchers can then consider how those cellular effects relate to blood-lipid profiles and cardiovascular disease risk. This framework connects molecular structure with physiological and public-health outcomes without treating any single level as isolated.
Trans fats matter beyond cell biology because industrial processing can create them during partial hydrogenation of vegetable oils. Their biological effects support nutrition research and help explain why food processing is relevant to health. The same evidence also informs public health policy, linking molecular changes in fats with population-level concern about cardiovascular disease risk.