Tumor Progression
Tumor Progression - Related Videos
02:07
Tumor Progression
0 Views •
2023
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages. Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07
Tumor Progression
0 Views •
2021
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages. Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
03:46
Bioluminescent Imaging of Breast Tumor Progression in a Female Mouse Model
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2025
Source: Marina Arantes Radicchi1, Victor Carlos Mello1, Victória Paz Machado1, Márcia Cristina Oliveira da Rocha1, Jaqueline Vaz de Oliveira1, Luana Cristina Camargo1,2, Luís Alexandre Muehlmann1, Ricardo Bentes Azevedo1, Sônia Nair Bao1, João Paulo Figueiró Longo11Institute of Biological Sciences, University of Brasília, 2Department of Basic Psychological Processes, Institute of Psychology, University of BrasíliaThis video demonstrates the procedure for tracking tumor progression in vivo by...
01:18
Thermally Responsive Biopolymer-Based Inhibition of Tumor Progression in a Rat Model
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2025
Begin with an anesthetized rat bearing a brain tumor composed of proliferating tumor cells.Expose the rat’s skull and create a hole to reveal the brain region with the tumor.Take a thermally responsive biopolymer fused with a cell-penetrating peptide and an inhibitor of c-myc, an oncogenic protein.Inject the biopolymer into the femoral vein of the hind limb for delivery to the brain.Apply infrared light through the skull hole to heat the tumor site, which induces biopolymer aggregation along...
07:12
Bioluminescence-Based Tumor Quantification Method for Monitoring Tumor Progression and Treatment Effects in Mouse Lymphoma Models
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Cited by 29 •
2016
Bioluminescence imaging is a well-known tool for localizing tumors and metastases, but quantification of these images often requires complex calculations and particular instruments. We describe the easy-to-use luminoscore method, based on precise acquisition conditions, requiring no calculations, and enabling tumor burden and treatment response to be monitored in mouse models.
FAQs
Clonal selection allows cell populations carrying advantageous alterations to become more prominent as tumor conditions change. Stromal, vascular, and immune cells contribute to this selective environment, favoring traits linked to persistent growth, survival, invasion, or dissemination. This dynamic process helps explain why tumors contain distinct subpopulations and why their behavior can change over time.
Genetic and epigenetic alterations can change signaling programs that regulate cell-cycle activity, cell survival, invasion, angiogenesis, and dissemination. Their accumulation gives abnormal cells multiple opportunities to acquire malignant traits, while different combinations across cell populations contribute to varied tumor behavior. These alterations therefore provide a biological basis for studying how malignancy develops and evolves.
Heterogeneity emerges when tumor cell populations accumulate different genetic and epigenetic alterations and experience different selective pressures within the microenvironment. As a result, cells in one tumor may differ in growth, survival, invasive capacity, or response-related biology. Recognizing this variation is important because a single tumor can contain multiple evolving populations rather than one uniform group of cells.
Assessment can focus on signaling changes associated with cell-cycle deregulation, resistance to cell death, angiogenesis, tissue invasion, and dissemination to distant organs. Examining these features helps connect molecular alterations with increasingly aggressive cellular behavior. Together, they provide a framework for relating changes inside tumor cells to larger outcomes such as invasion or metastasis.
Because progression reflects accumulating alterations, clonal selection, and changing interactions with the tumor microenvironment, researchers can search for biological features associated with disease risk or evolving malignancy. Biomarkers identified through this work may help distinguish relevant stages or states of tumor development. The broader goal is to improve understanding of risk and support more informed cancer research.
Understanding how tumors evolve identifies processes that may be interrupted therapeutically, including deregulated cell-cycle signaling, resistance to cell death, angiogenesis, invasion, and dissemination. It also highlights the importance of the surrounding stromal, vascular, and immune context. This biological perspective supports development of treatments intended to limit malignant evolution and improve patient outcomes.