Fiber Laser Irradiation
Fiber Laser Irradiation - Related Videos
14:18
Automation of Mode Locking in a Nonlinear Polarization Rotation Fiber Laser through Output Polarization Measurements
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Cited by 2 •
2016
A protocol to detect and automate mode locking in a pre-adjusted nonlinear polarization rotation fiber laser is presented. The detection of a sudden change in the output polarization state when mode locking occurs is used to command the alignment of an intra-cavity polarization controller in order to find mode-locking conditions.
08:48
Selective Area Modification of Silicon Surface Wettability by Pulsed UV Laser Irradiation in Liquid Environment
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Cited by 1 •
2015
We report on a process of in situ alteration of HF treated Si (001) surface into a hydrophilic or hydrophobic state by irradiating samples in microfluidic chambers filled with H2O2/H2O solution (0.01%-0.5%) or methanol solutions using pulsed UV laser of a relative low pulse fluence.
08:18
Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
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Cited by 30 •
2017
Confocal fluorescence microscopy and laser micro-irradiation offer tools for inducing DNA damage and monitoring the response of DNA repair proteins in selected sub-nuclear areas. This technique has significantly advanced our knowledge of damage detection, signaling, and recruitment. This manuscript demonstrates these technologies to examine single and double strand break repair.
07:11
Laser Micro-Irradiation to Study DNA Recruitment During S Phase
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Cited by 6 •
2021
This protocol describes a non-invasive method to efficiently identify S-phase cells for downstream microscopy studies, such as measuring DNA repair protein recruitment by laser micro-irradiation.
06:40
Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments
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Cited by 5 •
2021
A protocol is presented for automated irradiation of thin gold foils with high intensity laser pulses. The protocol includes a step-by-step description of the micromachining target fabrication process and a detailed guide for how targets are brought to the laser's focus at a rate of 0.2 Hz.
FAQs
These parameters determine how much energy reaches the target and how long tissue receives it. Tissue absorption then influences whether the response remains primarily a localized illumination effect or becomes heating sufficient to produce photothermal damage. Adjusting the combination allows cancer researchers to study controlled differences in tumor and surrounding-tissue responses.
Absorption links the delivered light to the biological effect at the irradiated site. When tissue absorbs enough energy to raise tumor temperature, localized photothermal damage can occur. Because absorption helps determine where and how strongly energy acts, it is central to interpreting treatment targeting and distinguishing effects in tumor tissue from responses in adjacent tissue.
The optical fiber directs coherent light to a selected site, supporting localized treatment rather than relying on broad illumination. This focused delivery is important in cancer research because investigators can examine site-specific heating and damage while considering responses of surrounding tissue. The approach therefore supports precise comparisons of target effects with nearby tissue effects.
Researchers select a target site, deliver laser energy through the optical fiber, and vary wavelength, power, or exposure time. They then assess the resulting effects in the tumor and surrounding tissue, including whether temperature elevation produced localized photothermal damage. This workflow helps identify treatment parameters that produce the intended degree of targeting.
It can support investigations of minimally invasive tumor ablation, treatment targeting, and biological responses to controlled irradiation. The method is especially useful when a study needs energy delivered at a selected tissue site while researchers examine the consequences for cancer cells and nearby tissue. These applications make it a platform for evaluating localized light-based interventions.
Studies can compare responses among cancer cells, tumor tissue, and surrounding tissue after controlled irradiation. They can also evaluate how changes in delivery parameters alter the biological effect, providing information for treatment optimization. In this context, the method helps investigate whether a light-based intervention could complement conventional therapies rather than being considered only as an isolated ablation approach.