Follicular Dendritic Cells
Follicular Dendritic Cells - Related Videos
11:39
T Cells Capture Bacteria by Transinfection from Dendritic Cells
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Cited by 2 •
2016
Here a protocol is presented to measure bacterial capture by CD4+ T cells which occurs during antigen presentation via transinfection from pre-infected dendritic cells (DC). We show how to perform the necessary steps: isolation of primary cells, infection of DC, DC/T cell conjugate formation, and measurement of bacterial T cell transfection.
09:04
Isolation of Mouse Lung Dendritic Cells
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Cited by 17 •
2011
A highly purified preparation of mouse lung dendritic cells is described. Specific emphasis is given to the isolation of conventional dendritic cell subset.
02:57
Bone Marrow-Derived Dendritic Cells Generation: A Method to Generate Dendritic Cells from Mouse Bone Marrow
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2023
This video describes a protocol for the generation of dendritic cells--key antigen-presenting cells that activate T cells--from the bone marrow of an adult mouse.
06:40
Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
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2025
This protocol outlines standardized methods to isolate and process follicular fluid, somatic cells, and immature oocytes from IVF procedures, enabling high-quality molecular and cellular analyses. These approaches support translational research into fertility, reproductive aging, and ovarian dysfunction using materials typically discarded in clinical care.
07:24
Xenopus Oocytes: Optimized Methods for Microinjection, Removal of Follicular Cell Layers, and Fast Solution Changes in Electrophysiological Experiments
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Cited by 5 •
2016
Optimized procedures for the isolation of single follicles, cytoplasmic RNA microinjections, the removal of surrounding cell layers, and protein expression in Xenopus oocytes are described. In addition, a simple method for fast solution changes in electrophysiological experiments with ligand-gated ion channels is presented.
FAQs
Complement and Fc receptors allow Follicular Dendritic Cells to capture and retain intact immune complexes on their surfaces. This retention keeps antigen available for repeated B-cell inspection within germinal centers rather than routing it primarily through processing pathways. The resulting display supports selection among B cells and helps sustain the antibody response by preserving access to antigen during this stage.
Retaining intact immune complexes creates a local antigen source that B cells can examine while undergoing selection in germinal centers. B cells that interact successfully with this displayed material can participate in the maturation process, which shapes the quality of antibody responses. Thus, FDC-associated antigen is relevant not only to immune organization but also to how effectively B-cell populations are selected.
The principal distinction is how these cell types handle antigen. Follicular Dendritic Cells retain intact immune complexes through complement and Fc receptors, whereas the overview contrasts them with conventional dendritic cells, which primarily present processed antigen. This difference places FDCs within the specialized environment of B-cell follicles and links their activity to germinal-center selection rather than primarily to processed-antigen presentation.
Within tumors, Follicular Dendritic Cells can contribute to the organization of tertiary lymphoid structures, which are local immune arrangements that include B-cell activity. Their presence may help shape how B cells are organized and function at the tumor site. Studying these networks therefore provides context for understanding whether local immune architecture supports or alters antitumor responses.
Examining where Follicular Dendritic Cells occur and how they function can help researchers interpret the immune organization of a tumor. Their distribution may indicate the presence or development of follicular or tertiary lymphoid features, while their function can clarify local B-cell activity. Together, these observations may help explain differences in tumor progression and patient prognosis.
FDC networks can influence the local B-cell environment and contribute to tertiary lymphoid structures within tumors. Because these structures shape local antitumor immunity, variation in FDC distribution or function may be associated with different responses to immunotherapy. Cancer researchers can therefore consider FDC-related organization as part of the broader immune context when interpreting treatment response and tumor behavior.