Mouse Brain Model
Mouse Brain Model - Related Videos
04:19
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Cited by 16 •
2017
Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.
04:58
Brain Metastasis Mouse Model: A Method to Generate Brain Metastasis Mouse Model by Intracarotid Cancer Cell Injection
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2025
This video demonstrates the establishment of a brain metastasis mouse model by intracarotid injection of fluorescently labeled cancer cells. The mouse model can be used to study the effects of novel therapeutics and the underlying physiological mechanisms.
08:32
Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
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Cited by 12 •
2017
We performed unilateral carotid artery occlusion on postnatal day 7-10 CD-1 mouse pups to create a neonatal hypoxic-ischemic (HI) model and investigated the effects of HI brain injury. We studied neurobehavioral functions in these mice compared to non-operated normal mice.
03:58
Generating a Traumatic Brain Injury Mouse Model Using an Impactor Probe
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2025
This video demonstrates the procedure for inducing an open-skull traumatic brain injury in a mouse by making a midline skull incision, drilling through the skull and removing the bone flap to expose the brain cortex, and applying high pressure to induce trauma. The wound is then sutured to prepare the mouse model for subsequent experiments.
08:02
Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model
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Cited by 9 •
2012
The purpose of this article is to describe the use of an orthotopic glioblastoma model for chemoradiation studies. This article will go though cell processing, implanting, and radiotherapy of the mouse using an intracranial model.
FAQs
These components create interacting conditions that cancer cells encounter within the brain rather than in isolation. Their presence allows investigators to examine how the surrounding environment influences tumor growth and invasion. This approach can reveal relationships between cancer cells and brain-associated tissues that may be missed when researchers study tumor cells without their local biological context.
The brain microenvironment can influence how different tumor types progress and respond to treatment. By examining glioblastoma and cancers that metastasize to the brain in this setting, researchers can connect tumor behavior with interactions among neural, vascular, and immune components. This provides context for interpreting differences in growth, invasion, and therapeutic response.
Investigators can track several linked outcomes, including tumor growth, invasion, treatment response, and survival. These measurements help connect molecular findings with observable disease progression rather than relying on a single endpoint. Examining multiple outcomes also supports evaluation of whether a therapeutic strategy changes tumor behavior or produces a broader improvement in disease course.
Cancer researchers may introduce tumor cells into the mouse brain to examine their behavior in the brain environment. They may also study tumors that reach the brain through metastasis. After establishing the relevant model, investigators follow changes such as growth and invasion and assess how the tumors respond to therapeutic interventions over the course of the experiment.
The model provides a setting in which researchers can examine therapeutic strategies in the presence of brain-associated tissue and tumor growth. This is important for studying whether a treatment reaches the relevant disease site and influences tumor behavior. Findings can be evaluated through treatment response and related measures of progression, helping connect delivery approaches with biological outcomes.
Researchers use it when they need to investigate tumor behavior within the brain and relate molecular observations to measurable disease outcomes. Applications include studying glioblastoma, examining metastatic tumors in the brain, tracking invasion and progression, and testing therapeutic approaches. The resulting data can also include survival measurements, which help assess the broader effect of an intervention.