Ureter Ligation
Ureter Ligation - Related Videos
01:22
Ureters
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2024
The ureters are retroperitoneal tubes located on either side of the vertebral column. They are responsible for transporting urine from each kidney to the urinary bladder. These tubes have thick walls and are approximately 25-30 cm long. Their diameter is around 10 mm at the renal pelvis, gradually narrowing to 1 mm as the ureter obliquely enters the posterior bladder wall through the ureteric orifices. The shape of these orifices is slit-like, which helps to prevent urine backflow toward the...
07:34
DNA Ligation Reactions
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2023
In molecular biology, ligation refers to the joining of two DNA fragments through the formation of a phosphodiester bond. An enzyme known as a ligase catalyzes the ligation reaction. In the cell, ligases repair single and double strand breaks that occur during DNA replication. In the laboratory, DNA ligase is used during molecular cloning to join DNA fragments of inserts with vectors – carrier DNA molecules that will replicate target fragments in host organisms. This video provides an...
01:11
Anatomy of the Genitourinary System I: Kidneys and Ureters
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2025
The upper urinary system comprises two kidneys and two ureters, which are crucial in filtering blood and forming urine.KidneysLocation and Structure:The kidneys are two bean-shaped organs positioned behind the peritoneum on either side of the spine.Kidneys are between the 12th thoracic (T12) and the 3rd lumbar (L3) vertebrae.The position of the liver causes the right kidney to sit slightly lower than the left.Protective Layers:Each kidney is enveloped in a tough, fibrous membrane called the...
11:53
Cecal Ligation Puncture Procedure
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Cited by 200 •
2011
The mouse model of cecal ligation and puncture as a valuable tool for the study of human sepsis.
05:47
Modified Technique for Coronary Artery Ligation in Mice
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Cited by 8 •
2013
The surgical procedure used to induce experimental myocardial infarction in mice begins with left thoracotomy between the third and the fourth ribs in order to visualize the anterior surface of the heart and left lung. The left coronary artery is ligated, the chest is closed and the mouse is allowed to recover spontaneously.
FAQs
Restricted urine movement raises pressure within the renal collecting system, placing stress on kidney tissue. This pressure is associated with hydronephrosis and can contribute to progressive renal injury. In experimental studies, the resulting changes provide a controlled way to examine how urinary obstruction alters kidney structure and function over the course of disease-related complications.
The obstructed kidney may undergo hydronephrosis, tissue remodeling, and inflammation, followed by progressive injury. These responses are important because they connect a mechanical change in urinary drainage with local biological consequences. Studying them helps researchers characterize how kidney tissue reacts when obstruction persists in settings relevant to urinary tract or pelvic disease.
Pelvic or urinary tract tumors can be associated with impaired urinary drainage, making obstruction a relevant complication of cancer. Ureter ligation helps isolate the effects of that mechanical obstruction on renal tissue and function. This separation can clarify which local responses and disease-related complications arise from blocked flow rather than from tumor biology alone.
The procedure establishes a controlled reduction or closure of ureteral flow, after which investigators examine the kidney’s response to the resulting obstruction. The study can then focus on changes such as collecting-system pressure, hydronephrosis, inflammation, tissue remodeling, progressive injury, or altered renal function. The exact evaluation depends on the research question.
Researchers may use the model when they need to study kidney consequences associated with obstruction from pelvic or urinary tract tumors. It supports investigation of how impaired drainage affects renal function and local tissue responses without requiring the obstruction itself to arise unpredictably. These findings can provide context for complications accompanying tumor-associated urinary blockage.
Because the obstruction is experimentally controlled, investigators can use the model to evaluate interventions intended to protect kidney tissue or restore urinary drainage. Outcomes may include the extent of hydronephrosis, inflammation, remodeling, progressive injury, and renal functional impairment. Comparing these responses with and without an intervention can indicate whether it reduces obstruction-related kidney damage.