Polydispersity Index
Polydispersity Index - Related Videos
07:53
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
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Cited by 8 •
2016
The most commonly used method for nanostructured lipid carrier (NLC) synthesis involves oil-in-water emulsion, homogenization and solidification. This was modified here by applying high shear dispersion after solidification to achieve a NLC with desirable size, improved drug encapsulation and drug loading efficiency as a potential carrier for dacarbazine delivery.
09:35
Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
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Cited by 71 •
2017
Here, we present a step-wise protocol for the dispersion of nanomaterials in aqueous media with real-time characterization to identify the optimal sonication conditions, intensity, and duration for improved stability and uniformity of nanoparticle dispersions without impacting the sample integrity.
08:48
Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants
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Cited by 15 •
2016
Existing methods for the modification of plants have limited applicability. The novel peptide-derived technology proposed here promises both simplicity and efficiency in the introduction of exogenous protein or genes into the desired intracellular compartments of intact plants.
11:59
In Situ Characterization of Boehmite Particles in Water Using Liquid SEM
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Cited by 5 •
2017
We present a procedure for real-time imaging and elemental composition analysis of boehmite particles in deionized water by in situ liquid Scanning Electron Microscopy.
FAQs
In dynamic light scattering, the instrument follows fluctuations in scattered light and forms an autocorrelation function. The cumulants method analyzes that function through its first and second cumulants, linking the second cumulant to the square of the first. This relationship yields the PDI used to characterize the breadth of a size distribution.
In colloid and nanomaterial analysis, PDI is obtained from light-scattering behavior associated with particle-size variation. Polymer dispersity instead uses the molecular-mass ratio Mw/Mn, combining weight-average and number-average molecular masses. Both describe distribution breadth, but they refer to different measured properties, so interpretation depends on the chemical system being examined.
A broad value signals that the sample contains a wider range of sizes, molecular masses, or another measured property, indicating lower uniformity. In practical chemistry, this pattern can help flag aggregation in colloidal or nanomaterial systems, variation between batches, or inconsistency introduced during synthesis or formulation.
Dynamic light scattering estimates PDI from fluctuations in light scattered by the sample. The measurement is represented through an autocorrelation function, and cumulants analysis extracts the first and second cumulants used for the reported value. The resulting number supports assessment of how consistently the analyzed material is sized.
PDI is useful when researchers need to judge consistency in colloids, nanomaterials, polymers, or formulated chemical systems. Comparing values can support decisions about whether a preparation is sufficiently uniform for drug delivery, catalysis, or advanced-material applications. It also helps investigate whether synthesis or formulation produces reproducible material characteristics.
For polymers, the Mw/Mn expression links distribution analysis to two complementary molecular-mass averages: the weight-average and number-average values. Examining this ratio helps researchers evaluate how consistently a synthesis produces a molecular-mass profile. It therefore adds chemistry-specific context because it concerns molecular-mass distribution rather than colloidal particle size.